Presents a historical overview of eukaryotic DNA replication by one of the legendary scientists in the field Reviews comprehensive compilation of the newest information on DNA replication Approaches issues related to DNA replication from various points of view Emphasizes the latest results on mechanistic and structural aspects of DNA replication Features the most recent development on the genome-wide view of where and when DNA replication starts and stops, and how those profiles are correlated with other genomic signatures Provides a novel concept for the highly adaptive and plastic mode of eukaryotic DNA replication

Autorentext
Hisao Masai, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Marco Foiani, IFOM, Instituto FIRC di Oncologia Molecolare, Milan, Italy

Inhalt
Preface.- Biography.- Chapter1. Historical Perspective of Eukaryotic DNA Replication.- Chapter2. Regulation of replication origins.- Chapter3. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells.- Chapter4. Initiation of DNA replication at the chromosomal origin of E. coli, oriC.- Chapter5. Initiation of DNA replication in the archaea.- Chapter6. Mechanism of lagging strand DNA replication in eukaryotes.- Chapter7. Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication.- Chapter8. Termination of eukaryotic replication forks.- Chapter9. Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex.- Chapter10. Architecture of The Saccharomyces cerevisiae Replisome.- Chapter11. Replication domains: genome compartmentalization into functional replication units.- Chapter12. Rif1-dependent regulation of genome replication in mammals.- Chapter13. G-quadruplexes and DNA replication origins.- Chapter14. Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions.- Chapter15. Chromatin replication and histone dynamics.- Chapter16. The temporal regulation of S phase proteins during G1.- Chapter17. Roles of SUMO in replication initiation, progression, and termination.- Chapter18. The multiple roles of ubiquitylation in regulating challenged DNA replication.- Chapter19. Regulation of mammalian DNA replication via the ubiquitin-proteasome system.- Chapter20. Coordinating replication with transcription.- Chapter21. Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites.- Chapter22. Cyclin E deregulation and genomic instability.- Chapter23. Replication through repetitive DNA elements and their role in human diseases.