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DNA Polymorphisms as Disease Markers

  • Kartonierter Einband
  • 172 Seiten
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Proceedings of a NATO ARW held in London, UK, September 26-28, 1990The purpose of this workshop was to assess the value of DNA pol... Weiterlesen
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Proceedings of a NATO ARW held in London, UK, September 26-28, 1990

The purpose of this workshop was to assess the value of DNA polymorphisms for the prediction, diagnosis or elucidation of aetiology for common metabolic diseases such as diabetes, hyperlipidaemia and atherosclerosis. The advent of recombinant DNA techniques has produced an explosion in knowledge of restriction site polymorphisms and hypervariable sequences around candidate genes for such common metabolic diseases as atherosclerosis, hyperlipidaemia and diabetes mellitus. These diseases are the major causes of morbidity and mortality in Western societies today. Since 1983 it has become apparent that there is much more variation in the frequency and sites of these DNA polymorphisms in human populations than was initially appreciated and that the majority of these DNA polymorphisms are only linkage markers for the disease. Consequently it was considered timely for laboratories involved in the mapping of these DNA mutations to meet together to discuss the implications of their studies. The main issues are whether such DNA polymorphisms will lead to an identification of major aetiological loci and which are the best techniques to achieve this? What is the cause of the differences in frequencies of such polymorphisms amongst world populations? Are such studies best conducted in homogeneous populations or in pedigrees? Are haplotypes, though more laborious to construct, a better way to proceed than analysis of single site polymorphisms? What are the consensus polymorphic sites that relate to the common metabolic diseases of diabetes, atherosclerosis and the hyperlipidaemias? The real need now to discuss the theoretical background behind the


Proceedings of a NATO ARW held in London, UK, September 26-28, 1990

Proceedings of a NATO ARW held in London, UK, September 26-28, 1990

Theoretical Background.- Genetic Approaches to Common Diseases.- A Candidate Gene Approach to the Genetics of Normal Lipid Variation: DNA Association Studies and Genotype by Environment Interaction.- Molecular Genetics Approach to Polygenic Disease - Initial Results from Atherosclerosis Research.- Diabetes.- Facilitative Glucose Transporters: Regulation and Possible Role in NIDDM.- Molecular Genetic Approach to Polygenic Disease: Dependent Diabetes Mellitus (NIDDM).- Lipids.- HDL and Reverse Transport of Cholesterol: Insights from Mutants.- Apolipoprotein E Polymorphisms and the Genetic Heterogeneity of Familial Dysbetalipoproteinaemia.- Abnormalities of Apolipoprotein B Metabolism in the Lipid Clinic.- Genetic Variation at the ApoA-I, CIII, A-IV Gene Complex: A Critical Review of the Associations between the Pst1 and Sst1 RFLPs at this Locus with Lipid Disorders.- The Molecular Basis of the Chylomicronemia Syndrome.- Lipoprotein Lipase Gene Variants in Subjects with Hypertriglyceridaemia and Coronary Atherosclerosis.- Atherosclerosis.- Atherosclerosis: The Genetic Analysis of a Multi-Factorial Disease.- RFLP Markers of Familial Coronary Heart Disease.- DNA Polymorphisms as Disease Markers.- Participants.


Titel: DNA Polymorphisms as Disease Markers
EAN: 9781461366409
ISBN: 1461366402
Format: Kartonierter Einband
Herausgeber: Springer US
Genre: Medizin
Anzahl Seiten: 172
Gewicht: 337g
Größe: H254mm x B178mm x T9mm
Jahr: 2012
Untertitel: Englisch
Auflage: Softcover reprint of the original 1st ed. 1991

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