Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Inhalt
1 Overview.- 2 DNA Photolyases.- 3 Cellular Responses to Methylation Damage.- 4 Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells.- 5 Nature of Lesions Formed by Ionizing Radiation.- 6 Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides.- 7 Biochemistry of Mammalian DNA Mismatch Repair.- 8 Short Patch Mismatch Repair in Mammalian Cells.- 9 Role of HMG and Other Proteins in Recognition of Cisplatin DNA Damage.- 10 TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation.- 11 DNA Polymerase Involvement in DNA Repair.- 12 Cellular Functions of Mammalian DNA Ligases.- 13 Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair.- 14 Transcriptional Responses to Damage Created by Ionizing Radiation: Molecular Sensors.- 15 Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress.- 16 Mechanisms for DNA Double-Strand Break Repair in Eukaryotes.- 17 Mutant Rodent Cells Defective in DNA Double-Strand Break Repair.- 18 Nucleotide Excision Repair: Its Relation to Human Disease.- 19 Cellular Responses to DNA Damage and the Human Chromosome Instability Syndromes.- 20 Genetics of Mismatch Repair, Microsatellite Instability, and Cancer.- 21 Mammalian Cell-Cycle Responses to DNA-Damaging Agents.- 22 Poly(ADP-Ribose) Polymerase in Response to DNA Damage.- 23 DNA Topoisomerases in DNA Repair and DNA Damage Tolerance.- 24 Molecular Approaches for Detecting DNA Damage.- 25 Radiation-Induced Damage and the Formation of Chromosomal Aberrations.- 26 Whole Organism Responses to DNA Damage: Modulation by Cytokines of Damage Induced by Ionizing Radiation.- 27 DNA Damage and Repair in the Clinic.