Award-winning researchers review of key aspects of DNA repair in a wide variety of organisms, including all-important model systems. The book focuses on DNA damage and repair in prokaryotic and model eukaryotic systems, emphasizing the significant progress that has been made in the past five years. Each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in cell cycle regulation.

Inhalt
Overview of DNA Damage and Repair, P. Hanawalt. Part I. Prokaryotic Responses to DNA Damage. Nucleotide Excision Repair in Escherichia coli , L. Grossman, C.-L. Lin, and Y. Ahn. Prokaryotic Base Excision Repair D. M. Wilson III, B. P. Engelward, and L. Samson. Oxidative DNA Damage and Mutagenesis, T. G. Newcomb and L. A. Loeb. Regulation of Endonuclease IV as Part of an Oxidative Stress Response in Escherichia coli, B. Weiss. The 'GO' System in Escherichia coli, J. H. Miller. The SOS Response, W. H. Koch and R. Woodgate. DNA Double-Strand Break Repair and Recombination in Escherichia coli, G. R. Smith. Transcription Repair Coupling in Escherichia coli , R. Bockrath. Branched DNA Resolving Enzymes (X-Solvases), B. Kemper. Dam-Directed DNA Mismatch Repair, Lene Juel Rasmussen, L. Samson, and M. G. Marinus. Translesion DNA Synthesis, Z. Hatahet and S. S. Wallace . DNA Repair and Mutagenesis in Streptococcus pneumoniae, S. A. Lacks. DNA Repair in Deinococcus radiodurans, J. R. Battista. Part II. DNA Repair in Lower Eukaryotes. The Genetics and Biochemistry of the Repair of UV-Induced DNA Damage in Saccharomyces cerevisiae, W. Siede. Double-Strand Break and Recombinational Repair in Saccharomyces cerevisiae, J. A. Nickoloff and M. F. Hoekstra. Pathways and Puzzles in DNA Replication and Damage Checkpoints in Yeast, T. Weinert and D. Lydal. Regulatory Networks That Control DNA Damage-Inducible Genes in Saccharomyces cerevisiae J. B. Bachant and S. J. Elledge. Mismatch Repair Systems in Saccharomyces cerevisiae, Gray F. Crouse. DNA Repair in Schizosaccharomyces pombe, D. J. F. Griffiths and A. M. Carr. Toward Repair Pathways in Aspergillus nidulans, E. Kafer and G. S. May. DNA Repair in Neurospora, A. L. Schroeder, H. Inoue, and M. S. Sachs. Pathways of DNA Repair in Ustilagomaydis, W. K. Holloman, R. L. Bennett, A. Cole-Strauss, D. O. Ferguson, K. Onel, M. H. Rendi, M. L. Rice, M. P. Thelen, and E. B. Kmiec. Processing of DNA Damage in the Nematode Caenorhabditis elegans, P. S. Hartman and G. Nelson. DNA Repair in Higher Plants, A. B. Britt.. Modes of DNA Repair in Xenopus Oocytes, Eggs, and Extracts, D. Carroll. Index.