Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertility

Broadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseases

Enriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases

Autorentext
Hiroyoshi Ariga
Faculty of Pharmaceutical Sciences, Hokkaido University
Sapporo, Japan

Sanae M.M. IguchiAriga
Faculty of Agriculture, Hokkaido UniversitySapporo,Japan

Inhalt

Preface.-Chapter 1 Introduction/Overview.- Chapter 2 Structural Biology of the DJ-1 Superfamily.- Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases.- Chapter 4 DJ-1 as an oncogene and its clinical significance.- Chapter 5 Role of DJ-1 in fertilization.- Chapter 6 Anti-oxidative stress function of DJ-1.- Chapter 7 Ttranscriptional regulation of DJ-1.- Chapter 8 Regulation of Signal Transduction by DJ-1.- Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal.- Chapter 10 DJ-1 as a biomarker of Parkinson's disease.- Chapter 11 Roles of DJ-1 in diabetes mellitus .- Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases.- Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy. <p