This book describes the plasmonic photothermal-assisted multimodal cancer therapeutics in the area of cancer nanotechnology or cancer nanomedicine. This book covers the fundamentals of plasmonic photothermal cancer therapy as well as plasmonic photothermal mediated multimodal cancer therapy. The various steps involved in developing such therapeutic modality, viz. (a) the selection of suitable nanoparticles, (b) synthesis of multifunctional nanocomposite, (c) optimization of the photosensitizer and chemotherapeutic drug loadings, (d) characterization of the synthesized nanocomposite, and (e) therapeutic evaluations through novel tumor-tissue mimicking phantoms and the cancer cell lines are discussed in detail. Apart from the detailed description of therapeutic outcome, this book provides a step-by-step approach to develop a multifunctional nanocomposite for such therapeutics. Overall, this book provides simplified and in-depth information about cancer nanobiotechnology to the researchers and graduate students in subject areas of nanotechnology, biotechnology and pharmaceutics to develop and contribute to such multimodal cancer therapeutics.

Presents comprehensive methodology to develop multifunctional nanocomposites Provides details on tissue phantoms for investigation of photothermal temperatures in solid tumor-like phantoms Includes detailed methodology for assessment of therapeutic outcome for multimodal cancer therapy

Autorentext
Dr. Divya Khurana is currently working as a project associate at Biomedical Applications Division, CSIR-CSIO, Chandigarh, India. She received her B.E. (Biotechnology) degree from the University Institute of Engineering and Technology, Panjab University, Chandigarh, India, in 2017, and was awarded with a gold medal for securing first position in B.E. Biotechnology. She obtained her Ph.D. (Engineering) degree from the Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India, at CSIR-CSIO, Chandigarh, India, in 2023. Her research interests include nanobiotechnology, plasmonic photothermal cancer therapeutics, multimodal cancer therapy, nanoparticle synthesis, and nanomedicine. She has published 04 papers in reputed peer reviewed international journals. She is also the winner of the CSIR international travel grant in 2023. Dr. Sanjeev Soni is currently a senior principal scientist in Biomedical Applications Division at CSIR-Central ScientificInstruments Organisation (CSIR-CSIO), Chandigarh, India. He obtained his B.E. (Mechanical Engineering) degree from the University of Madras, India, and Ph.D. (Engineering) from the Indian Institute of Technology Ropar, Punjab, India. His research interests include plasmonic photothermal cancer therapeutics, plasmonic sterilization, plasmonic photothermal-assisted drug delivery, nano-bio-photonics, tissue optics, and biological heat transfer toward biomedical devices. He has published 43 papers in reputed international and national journals, 28 papers in refereed conferences, and 04 book chapters. He received IETE-Hari Ramji Toshniwal Award in 2022 for the development of affordable high optical throughput light sources.

Inhalt

Fundamentals of Plasmonic Photothermal Therapy (PPTT)-assisted Multimodal Cancer Therapies.- Choice of Nanoparticles for PPTT-assisted Multimodal Cancer Therapy.- Synthesis and Characterization of Multifunctional Gold Nanoblackbodies (AuNBs).- Tissue-mimicking Phantoms for Photothermal Performance Evaluations.- In Vitro Evaluation of the Therapeutic Outcome of the Synthesized Nanocomposite.