Diagnosis and Therapy of Malignant Lymphoma

K. MUSSHOFF The group of diseases known as malignant lymphomas are, for a number of reasons, of equal interest to theoretical and clinical medicine. New findings in the fields of virology and immunology could conceivably shed some light on the so far unknown etiology of malignant lymphomas. A viral etiology could explain many of the dis parate findings with such a puzzling disease as lymphogranulomatosis, which shows both all the signs of malignancy, such as the characteristic Reed-Sternberg and Hodgkin cells and chromosome abnormalities, and those of an inflammatory disease, i.e. typical changes in the blood count and bone marrow and in the distribution of serum proteins. So far we have not been able to identify the etiology of this disease. However, clinical observations and pathomorphological investigations involving a joint effort by different branches of medicine have brought us closer to an understanding of the clinical picture. Descriptive anatomy has given us a clear picture of the regional distribution of the lymphatic system, which has long been neglected in the past. The introductory paper by Dr. S. KUBIK (Zurich), who has made valuable contributions to our knowl edge of the anatomy of the lymphatic system, deals with this subject.

Inhalt
Opening Address.- Opening Address.- Anatomy of Lymphoma.- The Anatomy of the Lymphatic System.- Pathology of Malignant Lymphoma.- A Functional Approach to the Classification of Malignant Lymphoma.- The Unspecific Mesenchymal Reaction of the Liver in Patients with Hodgkin's Disease.- Unspecific Mesenchymal Reaction in Bone Marrow in Patients with Hodgkin's Disease.- The Specific Post-Capillary Venules of Lymphoglandular Tissue in Hodgkin's Disease.- Immunopathology of Malignant Lymphoma.- Immunology and Immune Reactions in Malignant Lymphoma.- Correlation between ElBV Infections and Malignant Lymphomas.- Epstein-Barr Virus (EBV) in Lymphoid Cells from Patients with Hodgkin's Disease.- Investigative Procedures in Malignant Lymphoma and Results.- Mediastinoscopy and Thoracoscopy.- Roentgen Anatomy of the Lymphatic System.- Lymphographic Differential Diagnosis in Malignant-Lymphomas.- Lymphography in Clinical Stage III Hodgkin's Disease.- Alterations in Pulmonary Diffusion Capacity after Lymphangiography.- The Diagnostic Significance of Laparoscopy in Hodgkin's Disease.- Splenectomy. (Indications, Technique, Complications, Intraoperative Diagnostic Methods).- Changes in Blood Coagulation after Splenectomy.- Staging Laparotomy and Splenectomy in Hodgkin's Disease.- Preliminary Results of Laparotomy with Splenectomy in Patients Previously Treated for Hodgkin's Disease.- Influence of Extensive Biopsy Sampling at Laparotomy on Planning of Radiotherapy in the Non-Hodgkin Lymphoma.- Bone Marrow Biopsy in Malignant Lymphoma.- Radioisotope Investigations in Malignant Lymphoma.- Diagnosis of Malignant Lymphoma with 67Gallium.- Primary Extent, Later Extension and Stage as Factors in Therapy of Malignant Lymphoma.- Presentation and Progression of Hodgkin's Disease.-Reticulosarcoma and Lymphosarcoma, Pattern of Relapse and Spread.- Staging in Malignant Lymphoma (Hodgkin's Disease and Non-Hodgkin Lymphomas).- Therapy of Malignant Lymphoma.- Radiotherapy of Hodgkin's Disease and the Malignant Lymphomas.- Chemotherapy and Radiotherapy in the Management of the Malignant Lymphomas.- Clinical Trials of the European Organization for Research on Treatment of Cancer (E.O.R.T.C.).- Therapeutic Results in Malignant Lymphoma.- The Curability of Hodgkin's Disease.- The Curability of Lympho- and Reticulosarcomas.- Results of Therapy in Hodgkin's Disease: Freiburg i. Br. 19641971.- Radiotherapy of Reticulum-Cell Sarcoma: Results and Dose-Time-Relationship.- Radical Radiotherapy of Hodgkin's Disease. Lund 19441956 and 19671971.- Results of Radiotherapy of Malignant Lymphomas.- Present Results in the Treatment of Malignant Lymphomas. Results Obtained in a Series of 317 Cases.- Localization and Prognostic Importance of the Post-Radiotherapy Marginal Recurrence of Malignant Lymphomas.- Author Index.