This book offers an authoritative, comprehensive overview of the role of C-Peptide in type 1 diabetes. Coverage extends trom biochemical and molecular actions to animal studies to Covers inflammation, cardiovascular complications, neuropathy and nephropathy.

In Diabetes & C-Peptide: Scientific and Clinical Aspects , a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Comprehensive summary of latest evidence on C-peptide and evolving therapies Written by renowned international experts in the field Covers both research and clinical issues, including inflammation, cardiovascular complications, neuropathy and nephropathy Includes supplementary material: sn.pub/extras

Klappentext

In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Inhalt
Preface.- Foreword.- C-peptide and Insulin A Happy Marriage.- Peptide Interactions of Proinsulin C-peptide.- he Effect of Combined C-peptide and Zinc on Cellular Function.- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy.- Role of C-Peptide in the Regulation of Microvascular Blood Flow.- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy?.- Renoprotective Effects of C-Peptide in Type I Diabetes.- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy.- C-peptide and Type 1 Diabetic Encephalopathy.- C-peptide: a New Molecule with Anti-Inflammatory Properties.- C-peptide: Connecting Diabetes with Macrovascular Complications.- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes.- Proatherogenic Effects of C-Peptide.- Conclusions and Future Outlook.