Autorentext

Devendra Kumar currently working as an Assistant Professor at School of Pharmacy & Technology Management, NMIMS University, India. He was Post-Doctoral Fellow at Department of Cellular and Integrative Physiology, University of Texas, Health Science Center, San Antonio, USA. And obtained his Ph.D from Indian Institute of Technology (Banaras Hindu University), Varanasi, India. He received Extramural Grant from Indian Council of Medical Research (ICMR, file #IIRP-2023-5582/F1, Amount of project: 39,44,085) and has written more than 45 articles published in national and international journals, 9 patents (3 granted, 6 filed), 2 book chapters. He has citations of more than 681 with h-index 15 and i10 index of 21.

Shraddha Manish Gupta has more than 15 years of research and teaching experience and currently is an Assistant Professor at School of Health Sciences and Technology, UPES, Dehradun, India. He has completed B.Pharm and M.Pharm from NDMVP'S College of Pharmacy, Nasik (M.H.) in 2003, 2006 respectively and Ph.D from Oriental University Indore, India. She Secured 96 percentile in GATE-2004 conducted by IIT, Delhi. She worked as a Research Assistant in School of Pharmacy, Monash University, Malaysia. She was Mentor in CSIR-SRTP (2020) program under Interdisciplinary Approach for Sustainable Use of Resources project-13. She has written more than 10 articles published in Q1 international journals, 2 patents (1 granted, 1published) and 8 book chapters.

Nagendra Singh Chauhan obtained his M. Pharm, Ph.D from the Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar in 2006 and 2011. He is currently working as a Senior Scientific Officer Grade-II and Government Analyst at the Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur, Chhattisgarh, India. He has professional expertise in natural product isolation and phytopharmacology. He has written more than 75 articles published in national and international journals, 32 book chapters and edited five books. He has citations of more than 2700 with h-index 42 and i10 index of 38 (Google scholar) and Scopus h-index 15; 669 citations.

Kamal Shah has more than 18 years of research and teaching experience and currently working as Professor at the Institute of Pharmaceutical Research, GLA University, Mathura, India. He has completed B.Pharma from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) in 2003. He was gold medalist in B.Pharm., M.Pharm. from the Department of Pharmaceutical Sciences, Sagar University, Sagar, India and PhD from APJ Kalam University Lucknow, India. He has written more than 90 articles published in national and international journals, 20 book chapters and 05 edited books. His SCOPUS h index is 17, with 905 citations.

Klappentext

Alzheimer's disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.

This scholarly volume offers a comprehensive and integrative examination of Alzheimer's disease, combining cutting-edge research with clinical perspectives. Alzheimer's Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics:

• Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoring
• Exploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiology
• Emerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitors
• Advances in translational research featuring nanotechnology-based delivery systems and bioactive natural compounds
• Evidence-based lifestyle interventions integrating nutrition and physical activity in disease management Spanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.

By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer's disease.

Inhalt

1. Understanding Alzheimer's Disease: An Introduction, Pathophysiology, and Diagnosis 2. Alzheimer's Disease: The Role of Blood Brain Barrier and Strategy to Cross BBB 3. The Application of Vaccines in Alzheimer's Disease: Active and Passive Immunotherapies 4. Secretase-Related Interventions in Alzheimer's: , ß, -Secretase, -Secretase Inhibitors (GSIs), -Secretase Modulators (GSMs) and Natural Products as GSMs 5. A Potential Modulator in Alzheimer's Disease: SIRT2 Inhibitors 6. Therapeutic Potential of Caspase Inhibitors in Alzheimer's Disease 7. Calpain Inhibitors: A Promising Therapeutic Approach in Alzheimer's Disease 8. Acetylcholinesterase Inhibitors: A Viable Therapeutic Strategy for Alzheimer's Disease 9. Noncompetitive N-Methyl-D-Aspartate (NMDA) Antagonist for Prospective Alzheimer's Disease Treatments 10. Phosphodiesterase Inhibitors: A Promising Avenue for Modulating Cognitive Dysfunction in Alzheimer's Disease 11. Autophagy Enhancer: A Promising Therapeutic Approach for Alzheimer's Treatment 12. Therapeutic Potential of Receptor for Advanced Glycation End-Products (RAGE) Inhibitors in the Treatment of Alzheimer's Disease 13. Targeting Alzheimer's Disease Using Neurotrophic Agents and Mimetics: Current Strategies and Challenges 14. Metal Chelators: A Promising Avenue for the Development of Novel Therapeutics for Alzheimer's Disease 15. Apolipoprotein E Based Treatment Approach for Genetically High-Risk Alzheimer's Patients 16. Biomarkers: Diagnostic, Prognostic and Therapeutic Monitoring of Alzheimer's Disease 17. Non-Peptidic Anti-Aggregate Compounds: A Promising Avenue for Alzheimer's Disease Therapy 18. Translational Potentials of Nanotechnology-Based Interventions for Alzheimer's Disease 19. Target of the Neurodegenerative Diseases and Mechanism of the Potent Natural Molecule 20. Therapeutic Nutrition Strategies in Alzheimer's Disease 21. The Role and Importance of Exercise in Alzheimer's Disease