Leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of endocrine disease. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations-the basic processes governing prenatal development of the individual endocrine organs-and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders.

Includes supplementary material: sn.pub/extras

Inhalt
I Hypothalamus/Pituitary.- 1 Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis.- II Growth.- 2 Molecular Mutations in the Human Growth Hormone Axis.- 3 Normal and Abnormal Growth.- 4 Adult Growth Hormone Deficiency.- III Thyroid.- 5 Molecular Mechanisms of Thyroid Gland Development: Insights from Clinical Studies and from Mutant Mice.- 6 Fetal-Perinatal Thyroid Physiology.- 7 Thyroid Disorders in Children and Adolescents.- IV Calcium and Bone.- 8 Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism.- 9 Bone Physiology.- 10 Pediatric Bone Disease.- V Gonadal Development.- 11 Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis.- 12 Sexual Differentiation.- 13 Prenatal Androgens and Sexual Differentiation of Behavior.- 14 Normal and Precocious Puberty.- 15 Delayed Puberty.- VI Adrenal.- 16 Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis.- 17 Molecular Genetics of Adrenal Disease.