This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells.
Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer's Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

Comprehensive coverage ranges from basic biology of the sources of dental stem cells through recent developments in pre-clinical trials, stem cell reprogramming and more Presents recent advances in cellular molecular biology identifying five types of dental stem cells and their potential use for regenerative medicine Includes timely discussions of political, ethical, and legal issues related to the business opportunities, problems, and challenges in the applications of dental stem cells Includes supplementary material: sn.pub/extras

Autorentext

Fikrettin ahin received his PhD from the College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, Ohio. After completing his postdoctoral research at the same university and at the Pest Management Research Centre of Agriculture and Agri-Food Canada, he worked as an assistant professor in the Department of Plant Pathology, Ataturk University, in Erzurum, Turkey. Dr. Sahin is now a professor and chair of the Department of Genetics and Bioengineering, Yeditepe University, stanbul, Turkey. He is on the advisory board of several journals, a member of the Technology and Inonvation Support Programme (TEYDEP), a principal member of The Turkish Academy of Sciences, and many other prestigious scientific committees and initiatives. Prolifically and internationally published, Dr. Sahin's research focuses on dental stem cells in the contexts of isolation, maintenance, differentiation and possible use for particular regenerative approaches. His other research areas include molecular microbiology, phytopathology, stem cell and gene therapy, and cancer.
Ay egül Döan received her PhD from Yeditepe University in Istanbul, Turkey, where she is a postdoctoral researcher in the Department of Genetics and Bioengineering. She works with the Gene and Cell Therapy group at the University's Molecular Diagnostic Laboratory, and is a member of stem cell and cellular therapy societies in Turkey. Her research focuses on mesenchymal stem cells, gene and cell therapy, cancer and wound healing. Dr. Döan is currently working with dental stem cells obtained from wisdom teeth of young adults and the potential use of these cells in gene and stem cell therapy applications.
Selami Demirci received his PhD from the department of Genetics and Bioengineering at the University of Yeditepe in Istanbul, Turkey. He is currently a Research fellow at the same department. Dr. Demirci isa member of the Stem Cell and Cellular Therapies Society, Turkey, and has completed several projects on dental stem cell maintenance and differentiation towards desired cell lineages for a particular regeneration approaches. His ongoing studies includes gene functions in stem cell, wound healing and regenerative medicine.

Klappentext

This book explores dental stem cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells.

Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer's Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

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