Neurotransmitter Release and Its Modulation

Klappentext A uniquely comprehensive and integrated account of neurotransmitter modulation. Suitable for neuroscientists and non-specialists alike. Zusammenfassung Acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation! its biological significance and its clinical relevance. The clear illustrations and descriptions create a valuable and easy to use reference resource for both the non-specialist reader and neuroscientist alike. Inhaltsverzeichnis Part I. Neurotransmitter Release: 1. Mechanisms of exocytosis and the central role of calcium; 2. Co-transmission; 3. Models and mechanisms of neurotransmission; Part II. Modulation of Neurotransmitter Release: Basic Principles and Key Players: 4. Modulation of neurotransmitter release; 5. Modulation by autoreceptors; 6. Modulation by heteroreceptors; 7. Modulation by hormones and local tissue factors; 8. Modulation by corticosteroid hormones; Part III. Modulation of Neurotransmitter Release: The Cellular Mechanisms Involved: 9. Second messenger pathways in the modulation of neurotransmitter release; 10. Regulation of calcium influx as a basis for modulation; 11. Calcium-independent modulation; Part IV. Modulation of Neurotransmitter Release: Physiological Function: 12. In vivo evidence for presynaptic modulation; 13. Modulation of secretion from neurosecretory cells; Part V. Modulation of Neurotransmitter Release: Clinical Relevance: 14. Possible role of presynaptic receptors in hypertension; 15. Monoamine neurones and antidepressant treatments; 16. Modulation of neurotransmitter release by some therapeutic and socially-used drugs; 17. Beneficial therapeutic interventions via manipulation of presynaptic modulatory mechanisms.

Zusammenfassung
Acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation, its biological significance and its clinical relevance. The clear illustrations and descriptions create a valuable and easy to use reference resource for both the non-specialist reader and neuroscientist alike.

Inhalt

Part I. Neurotransmitter Release: 1. Mechanisms of exocytosis and the central role of calcium; 2. Co-transmission; 3. Models and mechanisms of neurotransmission; Part II. Modulation of Neurotransmitter Release: Basic Principles and Key Players: 4. Modulation of neurotransmitter release; 5. Modulation by autoreceptors; 6. Modulation by heteroreceptors; 7. Modulation by hormones and local tissue factors; 8. Modulation by corticosteroid hormones; Part III. Modulation of Neurotransmitter Release: The Cellular Mechanisms Involved: 9. Second messenger pathways in the modulation of neurotransmitter release; 10. Regulation of calcium influx as a basis for modulation; 11. Calcium-independent modulation; Part IV. Modulation of Neurotransmitter Release: Physiological Function: 12. In vivo evidence for presynaptic modulation; 13. Modulation of secretion from neurosecretory cells; Part V. Modulation of Neurotransmitter Release: Clinical Relevance: 14. Possible role of presynaptic receptors in hypertension; 15. Monoamine neurones and antidepressant treatments; 16. Modulation of neurotransmitter release by some therapeutic and socially-used drugs; 17. Beneficial therapeutic interventions via manipulation of presynaptic modulatory mechanisms.