The PI3K/AKT pathway plays a crucial role in metabolism, neurodegeneration, and cancer. It regulates insulin signaling, obesity, and metabolic disorders while offering therapeutic potential. Dysregulation of this pathway is linked to Alzheimer's disease, influencing oxidative stress, neuroinflammation, and mTOR signaling. In cancer, it drives progression through miRNA regulation and PI3K inhibitors. Understanding its molecular mechanisms provides insights into disease pathogenesis and targeted therapies. With its broad impact on cellular functions, the PI3K/AKT pathway remains a key focus in biomedical research, offering new opportunities for developing treatments across various health conditions.

Autorentext
Dalia Medhat, Professor of Medical Biochemistry at the National Research Centre, Egypt, is an expert in medical research and translational science. Her work focuses on cancer biology, stem cell therapy, nanomedicine, and harnessing natural compounds for treating diabetes, neurodegenerative diseases, and liver disorders.