A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

Includes supplementary material: sn.pub/extras

Klappentext
Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given micro-organism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses.
Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents.

Inhalt
Introduction: Cytokine Biology Relevant to Infectious Diseases.- I Cytokines in Infectious Diseases.- 1 Leptin: Its Role in Immunomodulation and Susceptibility to Infection.- 2 Cytokine Gene Polymorphism and Host Susceptibility to Infection.- II Cytokines in Gram-Negative Infections.- 3 Proinflammatory and Anti-Inflammatory Cytokines as Mediators of Gram-Negative Sepsis.- 4 Host Response to Pathogenic Bacteria at Mucosal Sites.- 5 Macrophage Migration Inhibitory Factor as a Cytokine of Innate Immunity.- III Cytokines in Gram-Positive Infections.- 6 Cytokine Patterns in Severe Invasive Group A Streptococcal Infections.- 7 Superantigens and Bacterial DNA as Cytokine Inducers in Gram-Positive Sepsis.- 8 Cytokines and Chemokines in Listeriosis.- IV Cytokines in Mycobacterial Infections.- 9 Regulation of Cytokines and Chemokines in Human Mycobacterium tuberculosis Infection.- 10 Cytokines and Chemokines in Protective and Inflammatory Responses to Infection with Nontuberculous Mycobacteria.- 11 Human Interleukin-12Interferon-? Axis in Protective Immunity to Mycobacteria.- 12 Role of Th1 Cytokines in Host Defenses Against Mycobacterium leprae.- V Cytokines in Other Bacterial Infections.- 13 Possible Role of Molecular Mimicry in Lyme Arthritis.- 14 Cytokine Responses in Patients with Pneumonia.- VI Cytokines in Fungal Infections.- 15 Cytokines and the Host Defense Against Aspergillus fumigatus.- 16 Cytokines of Innate and Adaptive Immunity to Candida albicans.- VII Cytokines in Parasitic Infections.- 17 Th1 and Th2 Cytokines in Leishmaniasis.- 18 Cytokines in the Regulation of Innate and Adaptive Immunity to Toxoplasma gondii.- VIII Cytokines in Viral Infections.- 19 Viroceptors: Virus-Encoded Receptors for Cytokines and Chemokines.- 20 Chemokines and Chemokine Receptors inHIV Infection.- 21 Cytokines in Viral Hepatitis.- IX Cytokines as Therapeutic Agents in Infectious Diseases.- 22 Interferon-? in the Treatment of Infectious Diseases.- 23 Interleukin-2 for the Treatment of HIV Infection.- 24 Clinical Applications of G-CSF and GM-CSF in the Treatment of Infectious Diseases.- X Anticytokine-Based Therapy in Treatment of Infectious Diseases.- 25 Anticytokine Therapies in Patients with Severe Sepsis and Septic Shock.- 26 Intravenous Immunoglobulin Adjunctive Therapy in Patients with Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis.