Cysteine Proteases of Pathogenic Organisms

This book covers all aspects of pathogen cysteine proteases, describing scientific advances made over the span of many years. Detailed coverate includes biochemistry, molecular biology and structure-function relationships of these important pathogen enzymes.

Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structurefunction relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research.

Written by leading researchers from Europe, Australia and North America Review recent developments in bacterial cysteine proteases Focuses on protozoan parasites of medical importance Covers cysteine proteases from helminths of medical and veterinary importance

Autorentext

MARK W. ROBINSON is a Chancellor's Postdoctoral Research Fellow at the Infection, Immunity and Innovation (i3) Institute at the University of Technology, Sydney (UTS), Australia. Robinson received a BSc (Hons) in Zoology (1999) and a PhD in molecular parasitology (2003) from Queen's University, Belfast (Northern Ireland). As a postdoctoral researcher, he worked on nematode proteomics and molecular biology at the University of Aberdeen (Scotland) until 2007 when he was awarded a prestigious Wain International Fellowship from the British Biotechnology and Biological Sciences Research Council (BBSRC) to continue his proteomics research at UTS (Australia). Robinson was awarded a UTS Chancellor's Postdoctoral Fellowship in 2008 which he currently holds as an independent researcher. His research interests include proteomics of hostpathogen interactions, structurefunction relationships of parasite immunomodulators and the molecular biology of helminth proteases.

Inhalt

Papa InLike Proteases Of Staphylococcus Aureus.- The LysineSpecific Gingipain Of Porphyromonas: Importance To Pathogenicity.- Falcipains And Other Cysteine Proteases Of Malaria Parasites.- Cathepsin Proteases In Toxoplasma Gondii.- Entamoeba Histolytica CathepsinLike Enzymes.- Cysteine Peptidases Of Kinetoplastid Parasites.- Cruzain: The Path From Target Validation To The Clinic.- The Phylogeny, Structure And Function Of Trematode Cysteine Proteases, With Particular Emphasis On The Fasciola Hepatica Cathepsin L Family.- Cathepsins B1 And B2 Of Trichobilharzia Spp., Bird Schistosomes Causing Cercarial Dermatitis.- Proteases In BloodFeeding Nematodes And Their Potential As Vaccine Candidates.- Cysteine Proteases From Bloodfeeding Arthropod Ectoparasites.- How PathogenDerived Cysteine Proteases Modulate Host Immune Responses.- Cystatins Of Parasitic Organisms