Cylindrospermopsin

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Beschreibung

Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. CYN is a polycyclic uracil derivative containing guanidino and sulfate groups. It is also zwitterionic, making it highly water soluble. CYN is toxic to liver and kidney tissue and is thought to inhibit protein synthesis and to covalently modify DNA and/or RNA. It is not known whether cylindrospermopsin is a carcinogen, but it appears to have no tumour initiating activity in mice. CYN was first discovered after an outbreak of a mystery disease on Palm Island, Queensland, Australia. The outbreak was traced back to a bloom of Cylindrospermopsis raciborskii in the local drinking water supply, and the toxin was subsequently identified. Analysis of the toxin led to a proposed chemical structure in 1992, which was revised after synthesis was achieved in 2000. Several analogues of CYN, both toxic and non-toxic, have been isolated or synthesised. C. raciborskii has been observed mainly in tropical areas, however has also recently been discovered in temperate regions of Australia, Europe, North and South America, and New Zealand.

Produktinformationen

Titel:

Cylindrospermopsin

Untertitel:

Freshwater, Cyanobacteria, Polycyclic compound, Uracil, Derivative (chemistry), Guanidine, Sulfate, Zwitterion, Solubility, Toxicity, Kidney, Protein biosynthesis, Liver, Covalent bond, RNA

Editor:

Frederic P. Miller

Agnes F. Vandome

John McBrewster

EAN:

9786130280819

ISBN:

978-613-0-28081-9

Format:

Kartonierter Einband

Herausgeber:

Alphascript Publishing