The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.

Inhalt
Section I: Biochemistry of Cyclic Nucleotides.- 1 Formation and Degradation of Cyclic Nucleotides: An Overview.- 2 Chemistry of Cyclic Nucleotides and Cyclic Nucleotide Analogs..- 3 Coupling of Receptors to Adenylate Cyclases.- 4 Acute and Chronic Modulation of the Responsiveness of Receptor-Associated Adenylate Cyclases.- 5 Guanylate Cyclase: Regulation of Cyclic GMP Metabolism..- 6 Cyclic Nucleotide Phosphodiesterase..- 7 Calmodulin Regulation of Cyclic AMP Metabolism..- 8 Radioimmunoassay Techniques for Cyclic Nucleotides.- 9 Immunocytochemistry of Cyclic Nucleotides and Their Kinases..- Section II: Biochemistry of Protein Phosphorylation.- 10 Protein Phosphorylation: An Overview.- 11 Cyclic AMP-Dependent Protein Phosphorylation.- 12 Cyclic GMP-Dependent Protein Phosphorylation.- 13 Calcium-Dependent Protein Phosphorylation.- 14 Photoaffinity Labeling of Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases.- 15 Nuclear Protein Phosphorylation and the Regulation of Gene Expression.