This volume presents a collection of reviews derived from work presented at the Aegean Conference: 5th Crossroads Between Innate and Adaptive Immunity. This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference Crossroads between Innate and Adaptive Immunity brought together leading international scientists and experts to address critical areas of Innate and Adaptive Immunity, a necessary step in the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive Immunity, and maximized scientific interchange through lecture presentations, poster sessions and informal discussions.

Edited by experts on vaccines and immune response Draws on research in multiple fields of immunologic research Covers research presented at the prestigious Aegean Conferences Includes supplementary material: sn.pub/extras

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Inhalt
Type III IFNs: Emerging Master Regulators of Immunity.- Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines.- The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses.- Functional Diversity of Human Dendritic Cells.- Selective Dependence of Kidney Dendritic Cells on CX3CR1: Implications for Glomerulonephritis Therapy.- Mechanisms of Memory T Cell Activation and Effective Immunity.- Molecular Programming of Immunological Memory in Natural Killer Cells.- Induction of Immune Tolerance to Dietary Antigens.- The Role of p110 in the Development and Activation of B Lymphocytes.- Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model.