This volume reviews key scientific principles and practices of passive antibody therapy for the treatment of infectious diseases. The main focus is on convalescent plasma, which is the most useful therapeutic option early in an epidemic, and may be especially important in low- and middle-income countries. The book's first section reviews the history of passive antibody therapies prior to the COVID pandemic, while the second section assesses convalescent plasma use during the COVID pandemic including evidence for safety and effectiveness, factors affecting efficacy, and the importance of convalescent plasma treatment of COVID-19 infections in the immunosuppressed. This section also addresses the roles played in the pandemic by monoclonal antibodies and hyperimmune globulins. Section three discusses the logistics of retrieving, storing and delivering convalescent plasma for therapy, and section four considers the role of passive antibody therapies in the event of a new pandemic involving an unknown microbial pathogen.

In March 2020 the editors of this volume founded the national COVID-19 convalescent plasma project (ccpp19), an association of academic physicians organized to investigate the safety and effectiveness of convalescent plasma and to facilitate access to its use in the treatment of this new international pandemic.

Since that time, the project has produced more than 100 papers on almost every aspect of convalescent plasma usage in COVID-19 treatment protocols, randomized trials, considerations of safety, conditions required for effectiveness, variability in use geographically and over time, application to vulnerable populations, regulatory issues, impact on overall COVID-19 mortality in the US and much else. At the same time, another form of antibody therapy monoclonal antibodies was being shown effective for out-patient use in COVID-19, confirming the principle of the value of antibody therapy in the early stages of disease, but lost effectiveness with viral mutation. A third form of antibody therapy hyperimmune globulin, a preventive therapy with an excellent historical record of efficacy in several infectious diseases - holds great potential but was not effectively developed for COVID-19. This edited work brings together the central findings gained over the past years about passive antibody use and serves as an indispensable guide to best practices in the use of antibody therapies.

Provides best practices for use of antibody therapies Reviews convalescent plasma application in COVID-19 infection Looks at the potential of antibody therapies for future epidemics

Autorentext

Nigel Paneth MD MPH is University Distinguished Professor Emeritus in the Departments of Epidemiology & Biostatistics and Pediatrics & Human Development in the College of Human Medicine at Michigan State University. He received his MD degree from Harvard University and trained in Pediatrics at the Albert Einstein College of Medicine/Jacobi Hospital in New York City. He obtained the MPH degree in Epidemiology from the Columbia University School of Public Health following his residency.

After faculty appointments at Einstein and Columbia, he moved to Michigan State University to establish a Department of Epidemiology in the College of Human Medicine. The unit began as a program in 1989, achieved departmental status in 1998, with Paneth as its first chair, and was renamed Epidemiology and Biostatistics in 2013.

His central research focus has been on the origins and consequences of brain damage originating in pregnancy and the perinatal period with a special focus on the problems of premature infants. He has authored more than 400 articles in the scientific press, many derived from three large NIH-funded long-term observational cohort studies of premature infants which he directed or co-directed - The Neonatal Brain Hemorrhage Study (1984-2004) the Developmental Epidemiology Network Study (1991-96) and Extremely Low Gestational Age Newborn Study (2001 present). Two scientific monographs emerged from these studies, with Paneth as co-author or editor - Brain Damage in the Preterm Infant (MacKeith Press, 1994) and Extremely Preterm Birth and its Consequences) MacKeith Press, 2014). He also co-edited the textbook: Cerebral Palsy: Science and Practice (McKeith Press, 2014). His interest in medical history, reflected in chapter 2 of this volume, is indicated by his co-authorship of Cholera, Chloroform and the Science of Medicine: A Life of John Snow (Oxford University Press, 2003).

He has received the Kathleen Lyle Murray award of the American Academy of Cerebral Palsy (with John L. Kiely), the **Weinstein-Goldenson Medical Science Award of the United Cerebral Palsy Research and Education Foundation and the Advancing Knowledge Award of the Coalition for Excellence in Maternal and Child Health Epidemiology.

During the COVID-19 pandemic Dr. Paneth was a member of the leadership team of the National Convalescent Plasma Project, which assisted in the deployment of convalescent plasma and which saved tens of thousands of lives in the United States.

Michael J Joyner MD is the Caywood Professor of Anesthesiology and Perioperative Medicine at the Mayo Clinic and Mayo Clinic College of Medicine in Rochester, Minnesota. He received his MD degree (1987) from the University of Arizona and trained in Anesthesiology at the Mayo Graduate School of Medicine. He participated in specialized research training in both programs.

After residency, in 1993 he was appointed to the staff of the Mayo clinic where he established the Human Integrative Physiology and Pharmacology laboratory in the Department of Anesthesiology and Perioperative Medicine. Over the years Joyner has been the Vice Dean for Research at Mayo, Vice Chair of the Department Anesthesiology and Perioperative Medicine, and a co-Principal Investigator for the institutions NIH funded GCRC and CTSA programs.

Joyner's central research focus has been on integrative physiological responses in humans to stressors like exercise, hypoxia, hyperthermia, and mental stress with a special emphasis on how sex differences and aging impact these responses. He has authored more than 600 articles in the scientific press and been funded by the NIH since the early 1990s. In addition to these interests and achievements, Joyner is considered one of the world's leading experts on human athletic performance. He has numerous publications on related topics including developing the physiological Joyner model of human endurance performance in the early 1990s.

He has received lifetime achievement awards from the American Physiological Society and the American College of Sports Medicine and an honorary doctorate from McMaster University (Canada). More than 30 of his former fellows have established independent laboratories at leading research institutions in the North America, Japan and Europe.

During the COVID-19 pandemic Dr. Joyner repurposed his physiologically oriented research program to focus on convalescent plasma and COVID-19. He was a member of the leadership team of the National Convalescent Plasma Project, which assisted in the deployment of convalescent plasma, and which saved tens of thousands of lives in the United States. Additionally, he was the principal investigator of the US Expanded Access Program for convalescent plasma. As the pandemic waned, he shifted his focus to the use of convalescent plasma in immunocompromised patients unable to generate endogenous antibodies. A highly effective use case the was fully licensed and approved by the US Food and Drug Administration in late 2024.

Arturo Casadevall , M.D., Ph.D., is a Bloomberg Distinguished Professor and Chair of the Department of Molecular Microbiology and Immunology at Johns Hopkins School of Public Health. He received his M.D. and Ph.D. degrees from New York University and completed his internship/residency in internal medicine at Belle…