Consensus on Hyperthermia for the 1990s

Hyperthermia as a safe and effective cancer treatment modality is rapidly evolving propelled by widespread research and clinical efforts worldwide. Presentations on Hyperthermia experience are now commonplace at Oncology meetings, as are congresses dedicated entirely to the intertwined interactions between basic sciences and patient treatment that together are forming the structure of a new medical specialty. Such was the XII International Symposium on Clinical Hyperthermia held in Rome, Italy, April 27 - 29, 1989. Papers presented therein constitute the backbone of this book. Biology research has provided data describing mechanisms of action for the cancer cell killing and physiological effects of Hyperthermia. Physics research has led to the development of equipment enabling treatment of many areas of the human body, as well as explained the limitations that still constrain our ability to treat, especially in the areas of deep seated tumor heating and non-invasive thermometry. The main question that will decide the future of this modality is that of its clinical use. To put it succinctly, what do we do with this potentially useful tool in an everyday clinical oncological practice . •• ? This is the main question addressed in this book as "Consensus on Hyperthermia for the 1990s. " The book in cludes 28 presented papers and 25 invited chapters from some of the leading experts in the field. Their basic mechanisms of action were physics principles, treatment quality assurance and especially, clinical indications.

Zusammenfassung
Proceedings of the Twelfth International Symposium held in Rome, Italy, April 27--30, 1989

Inhalt
Chapters.- Clinical Use of Regional Hyperthermia.- The Basis for Hyperthermia Becoming the 4th Cancer Treatment Modality.- Local Tumor Hyperthermia in the 1990s.- Consensus of Hyperthermia for the 1990s.- Micronuclei Assay-A Predictive Variable for Tumor Response to Treatment.- Instrumentation for Clinical Hyperthermia.- The Use of Hyperthermia in Cancer Treatment Thermotron RF-8.- Heat Shock Proteins.- Biochemical and Ultrastructural Changes in the Hyperthermic Treatment of Tumor Cells.- Interstitial Hyperthermia: Technical Problems and Methodology.- Conductive Interstitial Hyperthermia: A New Modality for Treatment of Intracranial Tumors.- Hyperthermia for the Treatment of Brain Tumors.- Hyperthermia and the Liver.- Quality Control of a Hyperthermia System.- Use of Local Hyperthermia for the Treatment of Benign Hyperplasia.- Extracorporeally Induced Total Body Hyperthermia for Disseminated Cancer.- Radiant Heat Systemic Hyperthermia Clinical Trials.- Whole Body Hyperthermia and Intraperitoneal Carboplatin in Residual Ovarian Cancer.- Overview of Whole Body Hyperthermia Experience at American International Hospital.- Hyperthermia and Chemotherapy.- Treating Advanced Melanoma with Hyperthermia in a Private Surgical Oncology Practice.- The Role of Hyperthermic Perfusion in the Treatment of Tumors of the Extremities.- Development of an Electrical Impedance Tomography System for Noninvasive Temperature Monitoring of Hyperthermia Treatment.- The Role of Paramedical Personnel in the Field of Clinical Hyperthermia: Past, Present, Future.- Procedures for Improving Therapeutic Gain.- Biological Response to Heat.- Perspectives and Hopes for the 1990s.- Papers.- Control of the Physical Parameters in Local Electromagnetic Hyperthermia.- Experimental Use of Extensive Pre-cooling ofSubcutaneous Fatty Tissue in Radiofrequency Capacitive Heating.- Four Element Computer Controlled 432 MHZ Phased Array Hyperthermia System.- Results of Deep Body Hyperthermia with Large Waveguide Radiators.- Superficial and Intraurethral Applicators for Microwave Hyperthermia.- Tripas: A Triple Applicator System with Relocatable Hot Spot at Tissue Depth.- Noninvasive Measurements in Hyperthermia: Radiometry and Previsional Thermometry.- Local Hyperthermia for Superficial and Moderately Deep Tumors-Factors Affecting Response.- Ultrasound and the Blood-Brain Barrier.- Clinical Experience with Local Hyperthermia in Rotterdam.- Whole Body Hyperthermia Experience in Breast Cancer at American International Hospital.- New Clinical Aspects of Whole Body Hyperthermia.- Thermal Induction and Temperature Control in the Hyperthermic Antiblastic Regional Perfusion with Extracorporeal Circulation.- Centered Radio-frequency Hyperthermia in Solid Tumors.- Local Hyperthermia for Deep Tumors.- Thermoradiotherapy of Deep Seated Tumors of the Pelvis with the APA and Sigma Applicator.- Intracavitary Hyperthermia Combined with HDR After Loading Irradiation in Vaginal Recurrences of Cervical Carcinoma.- Local Microwave Hyperthermia and Benign Prostatic Hyperplasia Induced Bladder Outlet Obstruction.- Thermoradiotherapy of Pelvic Tumors with the BSD 2000.- Radiosensitizing Effect of Hyperthermia in Radioresistant Tumors.- Hyperthermia and Hyperglycemia in Tumor Therapy.- Enhancing Thermoradiotherapy Efficacy by Hyperglycemia.- Influence of Hyperthermia on Experimental Viral Infections in Vitro.- Immunotherapeutical Strategies in Cancer Patients.- Coley Toxins The First Century.- Generation of Non MHC Restricted Cytotoxic Immune Responses: Effects of in Vitro HyperthermicTreatment.- Responses of Immune System to Hyperthermia.- Perspectives for the Combined Use of Photodynamic Therapy and Hyperthermia in the Cancer Patient.- Assessment of Combined Thermoradiotherapy in Recurrent Advanced Carcinoma of the Breast.- Local Hyperthermia for Treatment of Advanced Prostatic Carcinoma.- An Overview of the Role of Radiation Therapy and Hyperthermia in Treatment of Malignant Melanoma.- Clinical Relevance of Heat Shock Proteins.