The complexity of genome evolution has given birth to exciting challenges for computational biologists. A various range of algorithmic, statistical, mathem- ical techniques to elucidate the histories of molecules are developed each year and many are presented at the RECOMB satellite workshop on Comparative Genomics. It is a place where scientists working on all aspects of comparative genomics can share ideas on the development of tools and their application to relevant questions. This volume contains the papers presented at RECOMB-CG 2010, held on October 911 in Ottawa. The ?eld is still ?ourishing as seen from the papers presented this year: many developments enrich the combinatorics of genome rearrangements, while gene order phylogenies are becoming more and more - curate, thanks to a mixing of combinatorial and statistical principles, associated with rapid and thoughtful heuristics. Several papers tend to re?ne the models of genome evolution, and more and more genomic events can be modeled, from single nucleotide substitutions in whole genome alignments to large structural mutations or horizontal gene transfers.

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This book constitutes the proceedings of the 8th RECOMB International Satellite Workshop on Comparative Genomics, RECOMB-CG 2010, Ottawa, Canada, in October 2010. This workshop is devoted to bringing together scientists working on all aspects of comparative genomics, from computer scientists, mathematicians and statisticians working on novel computational approaches for genome analysis and comparison, to biologists applying these computational tools to study the structure and the evolution of prokaryotic and eukaryotic genomes. The 24 papers presented were carefully reviewed and selected from 35 submissions. The papers enrich the combinatorics of genome rearrangements, while gene order phylogenies are getting more and more accurate, thanks to a mixing of combinatorial and statistical principles, associated with rapid and thoughtful heuristics. Several papers tend to refine the models of genome evolution, and more and more genomic events can be modelized, from single nucleotide substitutions in whole genome alignments to large structural mutations or horizontal gene transfers.