Colorectal Cancer

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Includes supplementary material: sn.pub/extras

Klappentext
The rapid growth over the past decade in the number of options available to manage colorectal cancer patients has created a need to unify this scattered knowledge so that practitioners in one area of treatment can understand the expertise of colleagues working in other areas. In Colorectal Cancer: Multimodality Management, Leonard Saltz, MD, has brought together a team of leading clinical, surgical, and radiation oncologists, as well as those specialists involved in pain management, diagnostic imaging, and complementary medicine, to create a unified vision of the many new possibilities for managing colorectal cancer. Here the practicing clinician will find cutting-edge reviews on advances in diagnostic and therapeutic radiology and the surgical aspects of treating colorectal cancer, the major therapeutic agents, the currently available drugs for first- and second-line management of metastatic colorectal cancer, chemotherapy for adjuvant management, and local regional therapies. Additional reviews explain the molecular genetic events that occur in colorectal cancer, the new understanding of dietary and environmental factors, , possible strategies for prevention, pain control, and complementary and alternative medicine approaches, and sexuality and fertility in the colorectal cancer patient.
Evidenced-based, multidisciplinary, and cutting-edge, Colorectal Cancer: Multimodality Management provides busy oncologists, gastroenterologists, surgeons, and radiation therapists an authoritative review of the best currently available approaches to the prevention, diagnosis, and treatment of colorectal cancer.

Inhalt
I. Epidemiology/Prevention.- 1 Biology and Molecular Genetics of Colorectal Cancer.- 2 Epidemiological Trends in Colorectal Cancer.- 3 Dietary and Lifestyle Influences on Colorectal Carcinogenesis.- 4 Screening and Surveillance.- 5 Chemoprevention of Colorectal Cancer.- 6 Management of Hereditary Colon Cancer Syndromes.- II. Diagnostic and Therapeutic Radiology.- 7 Overview of CT, MRI, and Ultrasound in the Imaging and Staging of Colorectal Cancer.- 8 Virtual Colonoscopy for Colorectal Cancer Screening and Surveillance.- 9 Preoperative Staging of Rectal Cancer: Endorectal Ultrasound and Endorectal MRI.- 10 Nuclear Medicine in the Diagnosis and Management of Colorectal Cancer.- 11 Radiation Therapy of Resectable Rectal Cancer.- 12 Management of Locally Unresectable Rectal Cancer.- 13 Radiation Therapy for Hepatic Metastases.- III. Surgery of Colorectal Cancer.- 14 Surgical Pathology of Colorectal Cancer.- 15 Surgery of Colon Cancer.- 16 Laparoscopy in Colorectal Cancer Management.- 17 Management of Cancer in a Polyp.- 18 Surgery of Rectal Cancer.- 19 Conservative Management of Early-Stage Rectal Cancer.- 20 Surgical Management of Hepatic Colorectal Metastases.- 21 Resection of Colorectal Metastases to the Lung.- 22 Surgical Management of Peritoneal Surface Spread of Colorectal Cancer.- 23 Cryosurgical Ablation for the Management of Unresectable Hepatic Colorectal Metastases.- 24 Radiofrequency Ablation of Colorectal Metastases to the Liver.- IV. Medical Oncology.- 25 5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer.- 26 Clinical Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacology.- 27 Oral Fluoropyrimidines in Colorectal Cancer.- 28 Irinotecan in the Treatment of Colorectal Cancer.- 29 Oxaliplatin in the Treatment ofColorectal Cancer.- 30 TS Inhibitors and Antifolates.- 31 Adjuvant Therapy for Colon Cancer.- 32 Hepatic Artery Infusion.- 33 Intraportal and Intraperitoneal Chemotherapy for Colon Cancer.- 34 Molecular Markers of Chemotherapy Resistance in Colorectal Cancer.- V. Supportive Management.- 35 Cancer Pain Syndromes in Colorectal and Anal Cancers.- 36 Pain Management in Colorectal and Anal Cancers.- 37 Sexuality and Fertility in Patients with Colorectal Cancer.- 38 Complementary and Alternative Medicine Approaches in Colorectal Cancer.- VI. New Agents in Colorectal Cancer.- 39 Angiogenesis and Colorectal Cancer: From the Laboratory to the Clinic.- 40 Selected Targets and Rationally Designed Therapeutics for Patients with Colorectal Cancer: Future Drug Development.- 41 Vaccine Strategies for Colorectal Cancer.- 42 Gene Therapy Strategies for Colorectal Cancer.