A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Includes supplementary material: sn.pub/extras

Klappentext
Chronic lymphocytic leukemia (CLL) is the second most frequently encountered leukemia in North America and Europe, and the object of considerable research and treatment. In Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management, prominent physicians and researchers from the leading medical centers in the United States and Europe critically review the latest scientific advances in our understanding of the molecular genetics and biology of CLL and apply them to its best management. Their comprehensive reviews of the clinical aspects of CLL focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogeneic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several promising new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.
Cutting-edge and clinically focused, Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management offers today's hematologists and oncologists the opportunity to update their clinical knowledge and sort out the range of available therapies to provide optimal patient care.

Inhalt
I. Introduction.- 1 The Natural History of CLL: Historical Perspective.- II. Biology and Genetics.- 2 Genetics of B-Cell Chronic Lymphocytic Leukemia.- 3 Molecular Biology of Chronic Lymphocytic Leukemia.- 4 The Heterogeneous Origin of the B-CLL Cell.- 5 Pathogenesis of Impaired Cellular Immune Function in CLL.- 6 Cytokines and Soluble Molecules in CLL.- III. Clinical Aspects: Diagnosis.- 1 Immunophenotypic Differential Diagnosis and Cell Cycle Analysis.- 8 Common Cytogenetic Abnormalities.- 9 Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia.- IV. Clinical Aspects: Prognosis.- 10 Staging of Chronic Lymphocytic Leukemia.- 11 Prognostic Indicators of Chronic Lymphocytic Leukemia.- V. Clinical Aspects: Treatment.- 12 Guidelines for Clinical Management of CLL.- 13 Chemotherapy of Chronic Lymphocytic Leukemia.- 14 Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia.- 15 Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia.- 16 Immunotoxin Therapy of Chronic Lymphocytic Leukemia.- 17 New Treatment Strategies in Chronic Lymphocytic Leukemia.- 18 Gene Therapy of Chronic Lymphocytic Leukemia.- VI. Clinical Aspects: Complications.- 19 Infections in Patients With Chronic Lymphocytic Leukemia.- 20 Autoimmune and Hypersplenic Cytopenias.- 21 Clonal Evolution and Second Malignancies in B-CLL.- VII. Familial and Juvenile Chronic Lymphocytic Leukemia.- 22 Inherited Predisposition to Chronic Lymphocytic Leukemia.- 23 Young Patients With Chronic Lymphocytic Leukemia.