Central D1 Dopamine Receptors

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

Inhalt
Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia.- The D-1 Dopamine Receptor.- Biochemical Properties of D-1 and D-2 Dopamine Receptors.- Biochemical and Functional Characterization of Central Dopamine Receptors.- Dopamine D-1 and D-2 Receptor Selectivities of Agonists and Antagonists.- DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus.- Studies on Central D-1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline.- N-Ethoxycarbonyl-2-Ethoxy-1,2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function.- Pharmacological and Behavioral Effects of D-1 Dopamine Antagonists.- Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia.- Diminished D-2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements.- D-1 Dopamine Receptors and Arousal.