This 2-volume set covers the processes of cell fusion in health and disease, including fertilization, placentation, and cell fusion in cellular reprogramming and cancer vaccine development, and on the role of cell fusion in cancer development and progression.

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.

Up-to-date information about current knowledge in cell fusion Up-to-date information about cell fusion mediating molecules Comparison of cell fusion in physiological and pathophysiological processes Cell fusion becomes an interesting cellular feature as proliferation, differentiation, apoptosis and autophagy

Autorentext
Dr. Thomas Dittmar promovierte bei Prof. Dr. Manfred Steiner am Lehrstuhl für Finanz- und Bankwirtschaft der Universität Augsburg. Heute ist er als Associate Consultant bei der Booz, Allen & Hamilton GmbH beschäftigt.

Inhalt

Preface, Thomas Dittmar, Kurt S. Zänker; 1 Introduction, Thomas Dittmar, Kurt S. Zänker; 2 Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. Elegans, Lilach Friedlander-Shani, Benjamin Podbilewicz; 3 Role of SNAREs in membrane fusion, Bahnu P. Jena; 4 Molecular and cellular mechanisms of mammalian cell fusion, Xiaofeng Zhou, Jeffrey L. Platt; 5 Membrane fusions during mammalian fertilization, B.M. Gadella, Janice P. Evans; 6 Trophoblast fusion, Berthold Huppertz, Martin Gauster; 7 Macrophage fusion and multinucleated giant cells of inflammation, Amy K. McNally, James M. Anderson; 8 Molecular mechanisms of myoblast fusion across species, Adriana Simionescu, Grace K. Pavlath; 9 Cell-fusion-mediated reprogramming: Pluripotency of transdifferentiation? Implications for regenerative medicine, Daniela Sanges, Frederic Lluis, Maria Pia Cosma; 10 Cell fusion and tissue regeneration, Manuel Álvarez-Dolado, Magdalena Martínez-Losa; 11 Dendritic cell-tumour cell fusion vaccines, Walter T. Lee; Index