Catecholamines are important transmitter substances in the autonomic and central nervous systems. These two volumes provide a comprehensive presentation of the state-of-the-art of catecholamine research and development in the past 15 years. The volumes present in-depth reviews of topical areas of catecholamine research in which substantial progress has been made and which are of current interest to various theoretical and clinical disciplines. Each topic has been dealt with by an established expert. Clinical subjects of relevant importance are included. Catecholamines are of interest in pharmacology, physiology, biochemistry, as well as in neurology, psychiatry, internal medicine (cardiology, hypertension, asthma), ophthalmology and anesthesiology.

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10 Catecholamines in the Central Nervous System.- A. Central Catecholamine-Containing Neuronal Systems.- B. Regional Concentrations of Catecholamines in the Brain.- C. Biochemical Studies on the Neuronal Projections of the Catecholaminergic Cells.- D. Regional Turnover of Catecholamines.- E. References.- 11 Catecholamines and Behaviour.- A. Introduction.- B. Dopamine Systems.- C. Noradrenergic Systems.- D. Overall Conclusions.- E. References.- 12 Central Control of Anterior Pituitary Function.- A. Introduction.- B. Growth Hormone.- C. Prolactin.- D. Thyrotropin.- E. Gonadotropins.- F. Adrenocorticotropin.- G. References.- 13 Regulation of Catecholamine Development.- A. Introduction.- B. Prenatal Development.- C. Postnatal Development.- D. Concluding Observations.- E. References.- 14 ?-Phenylethylamine, Phenylethanolamine, Tyramine and Octopamine.- A. Introduction.- B. Methods.- C. Distribution.- D. Uptake, Storage and Release.- E. Metabolism.- F. Effects of Drugs on Tissue Levels.- G. Pharmacological Actions and Receptors.- H. Function in Pathological States.- I. Conclusions.- K. References.- 15 Plasma Levels of Catecholamines and Dopamines-?-Hydroxylase.- A. Introduction.- B. Measurement of Plasma Catecholamines.- C. Plasma Catecholamine Levels.- 1. Time-Dependent Variations in Plasma Catecholamines.- 2. Age, Sex and Race.- 3. Postural Changes.- 4. Muscular Work and Exercise Training.- 5. Hypoglycemia.- 6. Responses to Extremes of Temperature.- 7. Hypoxia, Hypercapnea and Acidosis.- 8. Hypotension, Hypovolemia, Hemorrhage and Shock.- 9. Mental Activity, Emotional Reactions and Stress.- D. Dopamine-?-Hydroxylase in Plasma.- E. Conclusion.- F. References.- 16 Dopaminergic Neurons: Basic Aspects.- A. Introduction.- B. Synthesis, Storage, Release, Uptake andMetabolism.- C. Regulation of Dopamine Synthesis and Release.- D. Dopamine Receptors.- E. Adaptive Changes.- F. Interaction of Dopamine and Other Neurons.- G. References.- 17 Catecholamines and Blood Pressure.- A. Introduction.- B. Morphological Aspects of the Central and Peripheral Nervous System Relevant to Blood Pressure.- C. Central and Peripheral Catecholamines in the Control of Blood Pressure in Animals and Man.- D. Animal Models of Hypertension and Their Relevance to Man.- E. Peripheral and Central Catecholamines in Hypertension in Animals and Man.- F. Adrenoceptor Agonists and Antagonists in Blood Pressure Regulation.- G. References.- 18 Sympathomimetic Amines, ?-Adrenoceptors and Bronchial Asthma.- A. Introduction.- B. Catecholamines.- C. Adrenoceptors.- D. References.- 19 Catecholamines Biochemical Genetics.- A. Introduction.- B. Biochemical Genetics of Catecholamine Biosynthesis.- C. Biochemical Genetics of Catecholamine Metabolism.- D. Conclusion.- E. References.- 20 The Role of Tyrosine Hydroxylase in the Regulation of Catecholamines Synthesis.- A. Introduction and Enzymology of Tyrosine Hydroxylase.- B. Assay of Tyrosine Hydroxylase.- C. Localization of Tyrosine Hydroxylase.- D. Short-Term Regulation of Tyrosine Hydroxylase.- E. Long-Term Regulation of Tyrosine Hydroxylase.- F. References.