The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes,their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.

Reviews stem cell-based, and cell-free therapy approaches for cardiovascular diseases Presents advances in cardiac progenitor cells (CPCs) development Discusses the role of pluripotent stem cells in valvulopathies

Autorentext

Dr. Khawaja Husnain Haider is currently a Professor of Cellular and Molecular Pharmacology (Stem cells and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards of various research journals and an invited reviewer for several respected international journals. His research focuses on using DNA, miRNAs, and stem cells as "drugs," a topic that has gained popularity in regenerative medicine. He has published nearly 325 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited seven books covering various facets of stem cells and their applications from drug to drug development.

Inhalt

Chapter 1_ Recent advances in in vitro generation of mature cardiomyocyte.- Chapter 2_ Cardiac Reprogramming with Stem Cells: An Advanced Therapeutic Strategy in Advanced Heart Failure.- Chapter 3_ Administration routes for advanced therapy medicinal products in patients with cardiovascular diseases.- Chapter 4_ Cardiac Progenitor Cells, their Derivatives and Therapeutic Applications.- Chapter 5_ Regenerative medicine: therapeutic insights from young cardiac stem cells.- Chapter 6_ Rejuvenation and regenerative potential of heart stem cells.- Chapter 7_ Cardiac Stem cells and utilization of atrial appendage microtissues or micrografts in the treatment of heart failure.- Chapter 8_ Stem cells and regenerative medicine in valvulopathies.- Chapter 9_ Cardiac tissue regeneration based on stem cell therapy.- Chapter 10_ Stem Cell Applications in Cardiac Tissue Regeneration.- Chapter 11_ Epicardial progenitors and stem cells in the cardiovascular applications.- Chapter 12_ Human myoblast genome therapy and the regenerative heart.- Chapter 13_ Exosomes and stem cell therapy.- Chapter 14_ Mesenchymal stem cells in the clinical perspective for myocardial regeneration and repair.- Chapter 15_ Towards the Human Induced Pluripotent Stem Cells (hiPSC)-derived Exosomes as Therapeutic Intervention for Cardiovascular Diseases.- Chapter 16_ Stem cell- derived extracellular vesicles as next generation tools in regenerative medicine.- Chapter 17_ Avant-garde Hydrogels as Stem Cell Niche for Cardiovascular Regenerative Medicine.- Chapter 18_ Stem cell-derived cardiac organoids: past, present and future.- Chapter 19_ Stem cell-based organoid engineering.- Chapter 20_ Cardiovascular Stem Cell Applications Animal Models.