This book surveys the latest vascular therapies, including small-diameter tissue-regenerative grafts, stent grafts and endovascular stents, prosthetic heart valves, and implantable cardiac pacemakers. Discusses cardiac diseases, advanced modelling and more.

This volume focuses on latest research in therapeutic devices for cardiovascular, i.e. vascular and valvular and cardiac diseases. In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular therapies focus on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation including the challenges posed on the prosthesis design. The section on cardiac diseases aims at covering therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices. A further section complements these three areas by presenting constitutive modelling of soft biological tissues of the cardiovascular system, an area imperative for advanced numerical and computational modelling in the development and optimisation of cardiovascular devices and therapies.

Focuses on latest research in therapeutic devices for cardiovascular and cardiac diseases Includes studies on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation Covers therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices Includes supplementary material: sn.pub/extras

Autorentext
Thomas Franz, geb 1962, Studium der Katholischen Theologie, Philosophie, Psychologie und Germanistik in Würzburg, Paris und Gießen. Diplom in Kath. Theologie 1989. Promotion in Philosophie 1998. Arbeitsschwerpunkte in den Bereichen Phänomenologie, Ontologie, Anthropologie, Ästhetik, Philosophischer Gotteslehre und Fundamentaltheologie.

Inhalt
Multi-objective design of a biodegradable coronary artery stent.- Development of a fabric-reinforced porous graft for vascular tissue engineering using finite element methods and genetic algorithms.- Aortic aneurysms: OSR, EVAR, stent-grafts, migration and endoleakcurrent state of the art and analysis.- Flexible leaflet polymeric heart valves.- Aortic biological prosthetic valve for open-surgery and percutaneous implant: Procedure simulation and performance assessment.- Cardiac restraint and support following myocardial infarction.- In vivo mechanical loading conditions of pectorally implanted cardiac pacemakers.