Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

Inhalt

1. Energy Costs of PVA and Emax: Constancy and Variability.- 2. Kinetic Property of Cardiac Myosin In Vitro1.- 3. Thin Filament Regulation and Cardiac Energetics.- 4. Explaining Load-Dependent Ventricular Performance and Energetics Based on a Model of E-C Coupling.- 5. Cardiac Contractions, PVA and Energetic Considerations Determined from a Cardiac Muscle Crossbridge Model.- 6. Normalization of Emax and PVA.- 7. Observations on the Relation of PVA and MVO2 in Closed Chest Dogs.- 8. Regional Myocardial Contraction Coupled with Energetics.- 9. Energetics During Ventricular Fibrillation.- 10. Influence of Preload on Non-Mechanical VO2 Assessed with 2,3-Butanedione Monoxime.- 11. Emax and Myocardial Microcirculation.- 12. Efficiency of Ventricular-Arterial Coupling and Baroreflex Regulation of Blood Pressure.- 13. Ventriculo-Arterial Load Matching of Failing Hearts.- 14. Calcium Signaling and Pharmacology of Cardiotonic Agents.- 15. Effect of Inotropic Agents on Mechanoenergetics in Human Diseased Heart.- 16. Effects of Various Inotropic Agents on the Relation Between Ventriculoarterial Coupling and Myocardial Energetics in Patients with Idiopathic Dilated Cardiomyopathy.