Cancer Stem Cell Markers and Related Network Pathways

This book entitled Cancer Stem Cell Markers and Related Network Path-ways is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype.
This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways.
The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters.
The topic of this book is particularly relevant to research in thefield of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.

Written by global experts in the field Contains interesting targets for anti-cancer therapy Reveals new mechanisms of Cancer Stem Cells

Autorentext

Shihori Tanabe, Ph.D. has been working as a Senior Researcher at the Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences from April 2016. From Apr 2005 until Jan 2006 she held a position of a Post Doctoral Fellow at the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo. From Feb 2006 until Mar 2010 she worked as a Researcher at the Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo Japan. She also had a position of a Senior Researcher at the Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences (Apr 2010 - Mar 2016, Tokyo Japan)

Klappentext

This book entitled "Cancer Stem Cell Markers and Related Network Path-ways" is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in thefield of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.

Inhalt

1. Epithelial-mesenchymal transition and cancer stem cells.- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance.- 3. ERBB signaling pathway in cancer stem cells.- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment.- 5. Microenvironment in cancer stem cells.- 6. Cancer stem cells contribute to drug resistance in multiple different ways.- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target.