This groundbreaking, multi-disciplinary title focuses on detection, measurement and interpretation of cancer precursors (defined as any lesion up to but not including invasive cancer, e.g. polyps as a pre-invasive lesion leading to colon cancer) at the most important sites where solid tumors occur, including the esophagus, colon, liver, etc. Evidence-based policy recommendations round out this essential volume of interest to pathologists, epidemiologists, cancer researchers, oncologists, and public health professionals.

Includes supplementary material: sn.pub/extras

Inhalt
Site-Specific Precancerous Conditions.- Biological Basis of Carcinogenesis.- Mechanisms and Biological Markers of Carcinogenesis.- Morphology of Cancer Precursor Lesions.- Issues Related to Measurement and Interpretation of Cancer Precursors.- Collection, Processing, and Analysis of Preneoplastic Specimens.- Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints.- Assessing Epidemiological Relations and the Role of Measurement Errors.- Site-Specific Precancerous Conditions.- Upper Aerodigestive Tract.- Esophagus.- Stomach.- Colon and Rectum.- Anus.- Liver.- Pancreas.- Lung.- Skin.- Breast.- Cervix.- Endometrium.- Ovary.- Vulva and Vagina.- Prostate.- Bladder.- Control of Cancer Precursors.- Screening.- Chemoprevention.- Evidence-Based Policy Recommendations on Screening and Prevention.- Conclusion.- Prospects.