Cancer Imaging with Radiolabeled Antibodies

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Zusammenfassung
` It is recommended for laboratory investigators who seek detailed information on many of the important issues in radioimmunodetection research and for clinical investigators active in this area, who will benefit from comparing a variety of viewpoints on the major problems that still need to be solved.'
Cancer Cells, 3:1, 1991

Inhalt
I. Historical and Theoretical Perspectives.- 1. Clinical radioimmunodetection: The second decade.- 2. Antibody targeting: Theoretical considerations.- II. Model Systems.- 3. Experimental model systems for antibody targeting and radioimmunodetection.- 4. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy.- 5. Physiology of monoclonal antibody accretion by tumors.- 6. Intraperitoneal delivery of monoclonal antibodies.- III. Radiochemistry.- 7. Chelates and antibodies: Current methods and new directions.- 8. Radiolabeling antibodies via the cyclic anhydride of DTPA Experiences of 5 years.- 9. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies.- 10. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate.- 11. Novel bifunctional linkers for antibody chelation with radiometals.- 12. Labeling of anti-tumor antibodies and antibody fragments with Tc-9m.- IV. Clinical Studies.- 13. Requirements for the use of radioimmunodetection of cancer in clinical practice.- 14. In-vivo antibody imaging for the detection of human tumors.- 15. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer.- 16. Tumor targeting with monoclonal antibody B72.3: Experimental and clinical results.- 17. Antibody imaging of endocrine tumors.- 18. Diversity of the human immune response to clinically used murine monoclonal antibodies.- V. New Approaches.- 19. Antibody lymphoscintigraphy.- 20. Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor.- 21. Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas.- 22. Anti-antibody enhancement oftumor imaging.