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Cancer Gene Therapy

  • Kartonierter Einband
  • 516 Seiten
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With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very excit... Weiterlesen
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With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.


This book brings together all major work achieved during the last decade in the exciting and promising field of cancer gene therapy, focusing on the achievements and definition of future goals. Providing a picture of the vectors available to carry genes in human tumours, it describes the available genes with different mechanisms of action as well as different systems that could be used for targeting tumour cells in humans. A comprehensive review of the important preclinical and clinical studies in cancer gene therapy, Cancer Gene Therapy should be of interest to experts as well as to newcomers to the field.


Preface. The Clinical Problem: 1. Management Problems in Oncology; S. J. Cleator, P. Price. Vectors: 2. Adenoviral Vectors; P. Seth. 3. Retrovirus Vectors; Y. Takeuchi, M. Pizzato. 4. Targetable Gene Delivery Vectors; P. L. Hallenbeck, S. C. Stevenson. 5. Human alpha-fetoprotein Transcriptional Regulatory Sequences: Application to Gene Therapy; T. Tamaoki. 6. Tumor-Targeted Salmonella: Highly Selective Delivery Vectors; D. Bermudes, et al. 7. Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells; M. Sunamura. 8. Polyoma and Papilloma Virus Vectors for Cancer Gene Therapy; N. Krauzewicz, B. E. Griffin. 9. Cochleates: Lipid-Based Vehicles for Gene Delivery Concept, Achievements and Future Development; L. Zarif, R. J. Mannino. 10. The Use of Skeletal Muscle to Express Genes for the Treatment of Cancer; G. Goldspink, M. Winslet. Cell Cycle Control: 11. Adhesion Molecules in Cancer Biology; Y. Ohene-Abuakwa, M. Pignatelli. 12. Cell Cycle Control; V. J. Tannoch, et al. Apoptosis: 13. Killer DR5: A Novel DNA-Damage Inducible Death Receptor Gene Links the p53-Tumour Suppressor to Caspase Activation and Apoptic Death; G. S. Wu, et al. 14. Apoptinâ ; A. Pietersen, M. H. M. Noteborn. 15. Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumours; A-M. Sandmair . 16. Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer; M-C. Hung, et al. Tumour Supressor Genes: 17. Pre-clinical Studies with Tumour Suppressor Genes; P. Seth. 18. Gene Therapy for Liver Tumours; R.R. Mitry, et al. 19. Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer; J. Kigawa, N. Terakawa. Other Systems: 20. Eliciting Hyperacute Rejection as a Tumor Killing Strategy: Herpes Amplicon Vector Transfer of the &agr; (1,3)Galactosyltransferase Gene; C.J. Link Jr, et al. 21. Innate Immune Therapy for Cancer: Seeking for Effective Molecules for Activation of the Innate Immune System; T. Seya, et al. 22. Mda-7: A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy; M.T. Madireddi, et al. Antisense and Ribozymes: 23. Antisense IGF and Antisense IGF-IR Therapy of Malignancy; H. Wang, et al. 24. Sensitisation of Tumours to Chemotherapy Through Gene Therapy; R. A. Gjerset, D. Mercola. 25. Design and Testing of Ribozymes for Cancer Gene Therapy; J.S. Norris, et al. 26. Ribozymes: Their Design and Use in Cancer; P.C. Turner. 27. The Approach of Triple Helix Formation in Control of Gene Expression and the Treatment of Tumours Expressing IGF-1; L.C. Upegui-Gonzalez, et al. Immuno-Modulation: 28. Dendritic Cell-based Immunization for Cancer Therapy; M.A. Morse, H.K. Lyerly. 29. Hybrid Cell Vaccination for Cancer Immunotherapy; P. Walden. 30. Modulation of the Immune Response Through 4-1BB; G. Sica, L. Chen. 31. Heat Shock Proteins in Cancer Therapy; K.V. Lukacs, et al. 32. Bi-Specific Antibodies in Cancer Therapy; H. Wang, et al. 33. B7.1 and Cytokines: Synergy in Cancer Gene Therapy; M. Kuiper, et al. 34. Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma; M.J. Mastrangelo, et al. Suicidal Genes: 35. Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT); C.J. Springer, I. Niculescu-Duvaz. 36. Bystander Effect; S. Freeman. 37. Adenoviruses as Gene Delivery Vectors; A-M. Sandmair, et al. Angiogenesis Control: 38. Evaluation of an Inhibitor of DNA Methylation, 5-aza-2-deoxycytidine, for the Treatment of Lung Cancer and the Future Role of Gene Therapy; R. L. Momparler, et al. 39. Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy; J. T. Nguyen. 40. Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy; J.T. Nguyen. Matrix Metallo Proteinase: 41. Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression for Cancer Gene Therapy; A.H. Baker, et al. Index.


Titel: Cancer Gene Therapy
Untertitel: Past Achievements and Future Challenges
EAN: 9781475773705
ISBN: 1475773706
Format: Kartonierter Einband
Genre: Medizin
Anzahl Seiten: 516
Gewicht: 772g
Größe: H235mm x B155mm x T27mm
Jahr: 2013
Auflage: 2002



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