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Cancer Clinical Trials

  • Kartonierter Einband
  • 288 Seiten
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The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, howev... Weiterlesen
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The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same time controversial: subgroup analysis and interactions, meta-analy sis of similar trials, consideration of subjective clinical opinions and those of the public at large, assessment of quality of life, pre vention trials, and so on. In February 1987 we took our third step along the road to evaluating these issues in dialogues between cli nicians, psychologists, legal experts, and statisticians. The talks presented at the meeting were revised by the authors afterwards and have been rearranged by the editors to form a strictly organ 1 2 ized book. The two preceding meetings in 1978 and 1981 focused strongly on adjuvant therapy in primary breast cancer, but this top ic served merely as a nucleus in the third meeting. This meeting, although called the Third Heidelberg Symposium was forced to leave Heidelberg and in fact was held in Freiburg. Without the interest and enthusiasm of Professor Martin Schu macher and his colleagues in Freiburg the meeting would never have taken place. The meeting was generously supported again by the Federal Ministry of Research and Technology (Bundesministe rium flir Forschung und Technologie, BMFT) within the framework of the West German BMFT Breast Cancer Study Group. We are grateful, in particular, to Mr. Hans W. Herzog for his personal in volvement. Juni 1988 H. Scheurlen, R. Kay, M.


The book is devoted to improved communication between clinicians, psychologists, and legal experts on the one hand and methodologists on the other. Mathematical formalism is therefore kept to a minimum and on a level acceptable to all sides. The contributions provide strictly organized coverage of the following topics: scientific fundamentals; heterogeneous treatment effects; combined information in historical controls, overviews, and comprehensive cohort studies; subjective opinions and informed consent; and assessment of quality of life. It is these aspects that are crucial in the planning of clinical trials and in the analysis and interpretation of results. Since there is still much debate between clinicians and statisticians on the subject, this book may prevent the reader from embarking on poorly planned clinical trials.


Contents: Scientific Fundamentals.- Heterogeneous Treatment Effects.- On Combining Information: Historical Controls, Overviews, and Comprehensive Cohort Studies.- Subjective Opinions and Informed Consent.- Assessment of Quality of Life.- Subject Index.


Titel: Cancer Clinical Trials
Untertitel: A Critical Appraisal
EAN: 9783642834219
ISBN: 3642834213
Format: Kartonierter Einband
Herausgeber: Springer Berlin Heidelberg
Genre: Medizin
Anzahl Seiten: 288
Gewicht: 502g
Größe: H244mm x B170mm x T15mm
Jahr: 2011
Auflage: Softcover reprint of the original 1st ed. 1988

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