Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.

Includes supplementary material: sn.pub/extras

Zusammenfassung
A reference survey on the identification and development of cancer chemopreventive agents. It reviews the relevant mechanisms of action, the criteria for populations benefiting from intervention, clinical study design, and early associated cellular and molecular biomarkers of carcinogenesis and focuses on molecular targets and mechanisms.

Inhalt
I. Antimutagens.- 1 Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane.- 2 Chemoprevention by Isothiocyanates.- 3 Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine.- 4 Modifiers of Cytochrome(s) P450.- II. Antiinflammatories.- 5 Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism.- 6 Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention.- 7 Lipoxygenases as Targets for Cancer Prevention.- 8 Inducible Nitric Oxide Synthase as a Target for Chemoprevention.- 9 Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil.- 10 Chemoprevention of Cancer by Curcumin.- 11 Prostacyclin and Lung Cancer Chemoprevention.- III. Nuclear Receptor Superfamily.- 12 Nuclear Receptor Superfamily: Targets for Chemoprevention.- 13 Prostate Cancer Chemoprevention: S?-Reductase Inhibitors.- 14 Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer.- 15 Aromatase Inhibitors as Chemopreventives of Breast Cancer.- 16 Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators.- 17 Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs.- 18 The Retinoids and Cancer Chemoprevention.- 19 Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs.- IV. Signal Transduction Modulators.- 20 ras Oncogene Inhibitors.- 21 The Potential of EGFR-Targeted Agents in Cancer Prevention.- 22 Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors.- 23 Therapeutic Strategies Targeting Polyamines.- 24 The Role of Phytoestrogens as CancerPrevention Agents.- 25 Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids.- 26 Development of an Inhibitor of raf Kinase.- 27 Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention.- 28 Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy.- V. Antioxidants, Vitamins, and Minerals.- 29 Chemoprevention by Fruit Phenolic Compounds.- 30 Tea Polyphenols as Cancer Chemopreventive Agents.- 31 Vitamin E as a Cancer Chemopreventive Agent.- 32 Vitamin C as a Cancer Chemopreventive Agent.- 33 Carotenoids.- 34 Lycopene, a Dietary Cancer Chemopreventive Agent.- 35 Not All Chemopreventive Selenium Compounds are Created Equal.- 36 Calcium.- 37 Folate and Cancer Chemoprevention.- 38 Conjugated Linoleic Acid as a Tumor Preventive Agent.- 39 Chemopreventive Effects of Omega-3 Fatty Acids.- VI. Agents Targeting Biological Processes Important in Cancer.- 40 Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention.- 41 Proteasome Inhibitors in Cancer Therapy.- 42 Modulation of DNA Methylation for the Treatment and Prevention of Cancer.- 43 Targeting Histone Deacetylase as a Strategy for Cancer Prevention.