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A Short History of the Drug Receptor Concept

  • Fester Einband
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The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the fir... Weiterlesen
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Beschreibung

The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.

Autorentext

CAY-RÜDIGER PRÜLL is Senior Lecturer in the History of Medicine at the University of Freiburg, Germany. Currently he is supervising projects on the history of pharmacology and on the history of German military medicine between 1914 and 1945. Between 2000 and 2003 he was Senior Research Associate at the University of Durham, UK, working on a project on the impact of the receptor concept on modern pharmacology, which was sponsored by the Wellcome Trust. He has published extensively on the history of medicine, pharmacology and pathology including Traditions in Pathology in Western Europe Theories, Institutions and their Cultural Setting. ANDREAS-HOLGER MAEHLE is Professor of the History of Medicine and Medical Ethics at Durham University, UK, where he directs the Centre for the History of Medicine and Disease. He previously held a lectureship at the University of Göttingen, Germany, and was a research fellow at the Wellcome Institute for the History of Medicine in London. He has published widely on the history of medicine and pharmacology, including Drugs on Trial: Experimental Pharmacology and Therapeutic Innovation in the Eighteenth Century. ROBERT F. HALLIWELL is Professor of Neuropharmacology at the Thomas J Long School of Pharmacy, University of the Pacific, in California. He previously held a lectureship in neuroscience at the University of Durham, UK and a research fellowship at the University of California, Irvine. His work focuses on the pharmacological properties of nerve cell receptors and ion channels.



Klappentext

The receptor concept was one of the most influential ideas in 20th-century medicine because it could account for the highly specific effects of drugs on the body. This book is the first to provide an historical discussion of its origin, development, slow acceptance into pharmacology and subsequent impact on modern medicine. It also considers the social context that influenced the drug receptor's development., making a valuable contribution to the history and understanding of modern medicine.

Inhalt

Introduction Paul Ehrlich and his Receptor Concept The Development of the Concept of Drug Receptors in the Physiological Research of J. N. Langley The Receptors and Scientific Pharmacology I: The Critics of the Receptor Idea and Alternative Theories of Drug Action, c. 1905-1935 The Receptors and Scientific Pharmacology II: The Critics of the Receptor Idea and Alternative Research Strands: The Transmitter Theory, c. 1905-1935 Quantitative Arguments for the Existence of Drug Receptors and the Development of the Receptor Occupancy Theory, c. 1910-1960 The Dual Adrenaline Receptor Theory of Raymond P. Ahlquist (1914-1983) and its Application in Drug Development between 1950 and 1970 The Emergence of Molecular Pharmacology Conclusions Archival Sources Bibliography

Produktinformationen

Titel: A Short History of the Drug Receptor Concept
Autor:
EAN: 9780230554153
ISBN: 978-0-230-55415-3
Format: Fester Einband
Genre: Naturwissenschaften allgemein
Anzahl Seiten: 239
Gewicht: 465g
Größe: H20mm x B225mm x T148mm
Jahr: 2009
Auflage: 2009

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