The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms.

This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book's mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies.

The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.

The only book available that covers in a single volume the many agents that provoke the full range of drug-induced allergic hypersensitivities and other adverse reactions Content is relevant to practitioners across the medical disciplines from clinicians and surgeons to nurses, pharmacists, dentists, and students New and expanded chapters address antimicrobials, drugs used in anesthesia and surgery, a wide range of biologics, opioids, anti-cancer drugs and vaccines

Autorentext
Brian A. Baldo (Retired) AUA (Pharmacy); BSc(Hons); PhDFormerly:Head, Molecular Immunology UnitKolling Institute of Medical ResearchRoyal North Shore Hospital of Sydneyand University of SydneySydney, NSW, Australia Nghia H. Pham (Retired)MSc; PhDFormerly:Molecular Immunology UnitKolling Institute of Medical ResearchRoyal North Shore Hospital of Sydneyand University of SydneySydney, NSW, Australia

Inhalt

Ch. 1. Adverse reactions to drugs and drug allergy.- Ch. 2. Classification and descriptions of allergic reactions to drugs.- Ch. 3. Mechanisms of hypersensitivity.- Ch. 4. Diagnosis of allergic reactions to drugs.- Ch. 5. Beta-Lactam antibiotics.- Ch. 6. Other antimicrobial drugs.- Ch. 7. Drugs and other agents used in anesthesia and surgery.- Ch. 8. Opioid analgesic drugs.- Ch. 9. Nonsteroidal anti-inflammatory drugs.- Ch. 10. Contrast media.- Ch. 11. Corticosteroids.- Ch. 12. Proton pump inhibitors.- Ch. 13. Targeted drugs for cancer therapy. Approved monoclonal antibodies.- Ch. 14. Non-targeted drugs for cancer therapy.- Ch. 15. Other approved therapeutic monoclonal antibodies.- Ch. 16. Other biologics.- Ch. 17. Vaccines.

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