A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.

Zusammenfassung
The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis.

Inhalt
I Etiology: Genetic Changes Associated with Breast Cancer.- 1 The Estrogen Receptor and Breast Cancer.- 2 Epidermal Growth Factor-Related Peptides and Their Cognate Receptors in Breast Cancer.- 3 The Role of Fibroblast Growth Factors in Breast Cancer Pathogenesis and Progression.- 4 Transforming Growth Factor-? and Breast Cancer.- 5 The Insulin-Like Growth Factor Network and Breast Cancer.- 6 Molecular Alterations in Breast Cancer.- 7 Apoptosis and the Development of Breast Cancer.- 8 WNT Genes and Breast Cancer.- 9 Hereditary Breast Cancer Genes.- 10 Biological Functions of the BRCA1 and BRCA2 Proteins.- 11 Psychosocial Issues in BRCA1/2 Testing.- II Biology of Tumor Progression: Breast Cancer Metastasis.- 12 Nm23, Breast Differentiation, and Cancer Metastasis.- 13 Role of Integrins in the Development and Malignancy of the Breast.- 14 Matrix Metalloproteinases in the Pathogenesis of Breast Cancer.- 15 The Urokinase Plasminogen Activation System in Breast Cancer.- 16 Angiogenesis in Breast Cancer: Role in Biology, Tumor Progression, and Prognosis.- III Therapeutics and Diagnostics: Diagnosis.- 17 Cytogenetic Approaches to Breast Cancer.- 18 Current and Future Directions in Surgical and Chemotherapeutic Approaches to Breast Cancer Treatment.- 19 Breast Cancer Therapy Using Monoclonal Antibodies Against Epidermal Growth Factor Receptor and HER-2.- 20 Towards the Therapeutic Targeting of Matrix Metalloproteinases in Breast Cancer.- 21 MUC1 Mucin as a Tumor Antigen in Breast Cancer.- 22 Aromatase Inhibitors and the Role of Hormonal Therapy in Breast Cancer.- 23 Drug Resistance in Breast Cancer.- 24 Smoking as a Risk Factor for Breast Cancer.- 25 The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants: Their Potential Roles in Breast Cancer.