Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma.

The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.

Highlights the most recent findings in the field of tumor biology, as well as the development of novel diagnostic procedures and therapeutic approaches in breast cancer Provides a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma

Klappentext

Breast Cancer is the most common tumor in women and it is the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.

Inhalt
The Genomic Basis of Breast Development and Differentiation.- Mammary Glands, Stem Cells and Breast Cancer.- The Genetics of Breast Cancer.- Alterations in Cell Cycle Regulatory Genes in Breast Cancer.- Neuregulins in the Nucleus.- Role of the EGF-CFC Family in Mammary Gland Development and Neoplasia.- Modeling Human Breast Cancer.- Gene Expression Profiling in Breast Cancer.- TGF-? Signaling.- DNA Methylation in Breast Cancer.- Signal Transduction Inhibitors in the Treatment of Breast Cancer.- Integration of Target-Based Agents in Current Protocols of Breast Cancer Therapy.