Autorentext
Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute's Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society. Dr. Zhang's research interests include 3D bioprinting, organ-on-a-chip, biomaterials, regenerative engineering, and bioanalysis. His scientific contributions have been recognized by over 40 regional, national, and international awards. He has been invited to deliver more than 170 lectures worldwide and has served as reviewer for more than 700 manuscripts for as many as 60 journals. He is serving as Editor-in-Chief for Microphysiological Systems and is Associate Editor for Bio-Design and Manufacturing, Nano Select, Aggregate, Nano TransMed, and Essays in Biochemistry. He is also on the Editorial Board of Biofabrication, Bioprinting, Advanced Healthcare Materials, Regenerative Biomaterials, Discover Materials, BMC Biomedical Engineering, Materials Today Bio, Bioengineering, Pharmaceutics, Materials Futures, Biomedical Engineering and Computational Biology, International Journal of Bioprinting, and Chinese Chemical Letters, Editorial Advisory Board of Biomicrofluidics, International Advisory Board of Advanced NanoBiomed Research and Advanced Materials Technologies, and Advisory Panel of Nanotechnology. At leisure (if any), Dr. Zhang enjoys bird- and nature-watching, traveling, photography, and technology

Klappentext
Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

Inhalt

1. The Concept of Organ-on-a-Chip and Body-on-a-Chip Devices
2. Advances in Three-Dimensional Cell Culture
3. Organoids and Spheroids
4. Microfluidics
5. Materials for fabricating Micro-physiological Systems
6. Design and Engineering of Multi-organ Systems
7. Recent Trends in Microfluidic Platforms for Body-on-a-chip systems
8. Chapter Microfabrication Techniques for Making Organ-on-a-Chip and Body-on-a-Chip Devices
9. Combining 3D bioprinting with organ-on-a-chip technology
10. Incorporating Biological Components within Organ-on-a-Chip and Body-on-a-Chip Systems
11. On-chip Sensing and Data Analysis from Multi-organ Systems
12. Liver-on-a-chip
13. Lung-on-a-chip
14. Lung-on-a-chip As a Model for Studying Effects of Cigarette Smoke
15. Kidney-on-a-chip
16. Adrenals-on-a-Chip
17. Heart-on-a-chip
18. Pancreas-on-a-Chip
19. Spleen-on-a-Chip
20. Skin-on-a-Chip
21. Blood Vessels-on-a-Chip
22. Bone-on-a-Chip
23. Cartilage-on-a-Chip
24. Muscle-on-a-Chip
25. Bladder-on-a-Chip
26. Testis-on-a-Chip
27. Ovary-on-a-chip
28. Thyroid-on-a-Chip
29. Thymus-on-a-Chip
30. Brain-on-a-Chip
31. Salivary glands-on-a-Chip
32. Bone marrow on a Chip
33. Human Organ-on-a-Chip Models for Diseases
34. Cancer-on-a-Chip
35. Modeling Disease Pathogenesis Using Organ-on-a-chip Platforms
36. Organ-on-a-chip using stem cells
37. Role of Body-on-a-chip Technology in Drug Discovery and Development
38. Computational Pharmacokinetic Modeling of Body-on-chip Devices
39. Drug and Toxicity Screening Using Multi-organ Systems
40. Micro-physiological Systems for Screening Environmental Toxins and Pollutants
41. Challenges in Manufacturing and Commercial Use of Body-on-a-chip and other Micro-physiological Devices
42. Body-on-chip Devices and the Regulatory Agencies
43. Body-on-chip Systems and Clinical Biomarkers Discovery
44. Body-on-chip Systems and chemical agents
45. Body-on-chip Systems and viral agents
46. Body-on-chip Systems and omics
47. Body-on-chip Systems and artificial intelligence- pathways for the future