Biotechnology Applied to Inflammatory Diseases

Biotechnology involves an interdisciplinary science that provides an interface between biological, molecular and cellular aspects of living organisms with broad technologies applicable in the fields of health, environment and materials. This book Biotechnology applied to inflammatory diseases: Cellular mechanisms and nanomedicine is focused on elaborating especially on two trendy areas from Biotechnology. In this volume, different inflammatory pathologies in terms of cellular and molecular mechanisms are characterized to better understand the science behind current precision medicine. The second part of the book focuses on the main biotechnological advancements for the understanding of the molecular mechanisms involved in the progression of various types of inflammatory diseases, highlighting up-to-date contributions of nanomedicine. The reader will be able to explore the utilization of technologies for various inflammatory diseases and will be able to enable an engaging and valuableknowledge for further research and clinically applied scenarios.

Explains cellular mechanisms and nanomedicines to understand inflammatory diseases treatment Discusses current advances in biotechnology for clinical approaches Inspires discovery and treatment of inflammatory diseases

Autorentext

Dr. Daniele Ribeiro de Araujo is Associate Professor of Pharmacology in the Human and Natural Sciences Center at Federal University of ABC (UFABC), Santo Andre, SP, Brazil. Before joining UFABC, she completed her postdoctoral research in biopharmaceutics and pharmacokinetics (University of Parma-Italy) and obtained master's and PhD degrees in functional and molecular biology (State University of Campinas, Campinas, São Paulo, Brazil) and bachelor's degree in pharmacy (Federal University of Maranhão, São Luís, Maranhão, Brazil). Her current research interests include the design and development of nanomedicines systems for the treatment of inflammatory diseases. In particular, her research group activities are devoted to the nanobiomaterials, nanobiotechnology, biopharmaceutics, and biochemical pharmacology fields, looking forward to the development of novel drug-delivery systems for parenteral and skin delivery. Dr. de Araujo has published several original reports and book chapters and is inventor or co-inventor of several patents. Dr. de Araujo is also a member of editorial boards and scientific societies and is recipient of research grants in nanomedicine and pharmacology fields.

Dr. Marcela Sorelli Carneiro Ramos is Associate Professor of Morphofunctional Sciences in the Human and Natural Sciences Center at Federal University of ABC (UFABC), Santo André, SP, Brazil, where she was provost of research from 2015 to 2018. She has completed her postdoctoral research in molecular biology (University of São Paulo, Institute of Biomedical Sciences) and holds a PhD in cellular and tissue biology (University of São Paulo, São Paulo, Brazil) and a Bachelor of Biomedicine (University of Santo Amaro). Her research group capabilities involve cellular and molecular biology as well as gene expression analysis on inflammation, immune system, cardiovascular physiology, renal insufficiency, and electrophysiology. Dr. Carneiro-Ramos' research focus is the study of renal injury-induced cardiac alterations and their role on immune system and systemic inflammation aspects. She is author and co-author of several original and review articles and is recipient of research grants on cardiovascular and inflammation fields.

Inhalt
Part 1. Cellular and molecular mechanisms in inflammatory diseases.- Chapter 1. Vascular Diseases as mediator of systemic inflammation.- Chapter 2. Inflammation and gut microbiote.- Chapter 3. Cardioimmunology: na interdisciplinar approach.- Chapter 4. Cell therapy as strategy for respiratory Diseases.- Chapter 5. Mitochondrial dysfunction as a trigger of inflammation in cardiovascular diseases.- Chapter 6. Cancer therapy-induced inflammation and its consequences.- Chapter 7. Coupling glucose phosphorylation to oxygen in brain mitochondria: would it be redox set point?.- Chapter 8. Methods for the analysis of arachidonic acid-derived metabolites in platelets.- Part 2. Nanomedicines for inflammatory diseases.- Chapter 9. In vitro models and molecular markers for assessing nano-based systems inflammatory potential.- Chapter 10. Using micro- and nanocarriers for myocardial targeted delivery.- Chapter 11. Nano-based hydrogels for atopic dermatitis treatment.- Chapter 12. Nanomedicine applied to inflammatory bowel diseases.- Chapter 13. Nanomedicine therapies for macrophage-targeted delivery.- Chapter 14. Nano-based therapies for pulmonary inflammatory diseases.- Chapter 15. Pulmonary inflammation treated by nanocarriers.