To detect, quantify, and model biologically signi?cant molecules is getting more and more important in our everyday life, in medicine, industry, and environment. When a group of enthusiasts like Frieder Scheller started more than 40 years ago to develop biosensors, they would not foresee that biosensors are nowavailableineverydrugstore,thatthehumangenomesequenceisavailable on the Internet, that DNA tests help in forensic cases, that we can track down thepathofourancestorsfromAfrica... This allis bioanalytics in practice! FriederSchellerisoneofthepioneersofthis?eld.So,wedidnothesitatefor longwhenThomasScheper,theSeriesEditor,askedustocompileamonograph th writtenbytheleadingspecialist tohonorhis65 birthday withafreshinsight into the ever expanding bioanalytical ?eld. Thanks to all contributors and thanks to the staff at Springer Verlag: Birgit Kollmar-Thoni, Ulrike Kreusel and Dr.Marion Hertel fortheir help! st Even in the 21 century biosensors will continue to play an important role in bioanalytics. By de?nition biosensors are characterized by a rather close contact of the biocomponent for recognition and the transducing element. Thus,thedevelopment ofbiosensors isahighlyinterdisziplanary ?eld.Future developments can be particularly seen in sensitivity enhancement down to the molecular level, switchability of the sensing device, miniaturization and integration into microsystems, incorporation of new transduction and ch- acterization methods and the use ofarti?cial recognition elements. This book tries to cover recent developments in order to illustrate the potential of thisrather fascinating area of science. Atthestartofthebook,youwill?ndachapteraboutthehistoryofbiosensors and Frieder Scheller s contribution. It gives you an impression what this re- less,unsel?shandcreativescientisthasdone.Tounderlinethebasicbiosensor idea we start here with a cartoonabout Frieder Scheller s work: XII Preface Aller guten Dinge sind drei ( all good things are 3 , as Germans believe). They all may partly characterize Frieder: Chancefavorsonlythepreparedmind.

Covers trends in modern biotechnology All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated More information as well as the electronic version available at springer.com Includes supplementary material: sn.pub/extras

Zusammenfassung
With contributions by numerous experts

Inhalt
Frieder Scheller and the Short History of Biosensors.- Protein Electrodes with Direct Electrochemical Communication.- Protein Engineering and Electrochemical Biosensors.- Artificial Receptors.- New Trends in Immunoassays.- Electrochemical Biochips for Protein Analysis.- Impedance Spectroscopy and Biosensing.- Amplified Transduction of Biomolecular Interactions Based on the Use of Nanomaterials.- Photoelectrochemical and Optical Applications of Semiconductor Quantum Dots for Bioanalysis.- Microsystems Technology and Biosensing.- Development of Microbial Sensors and Their Application.- Strategies for Label-Free Optical Detection.- DNA Microarrays.- Scanning Electrochemical Microscopy (SECM) as a Tool in Biosensor Research.