The NATO Advanced Study Institute on Biomechanics of Active Movement and Division of Cells was held September 19-29, 1993 in Istanbul and the Proceedings are presented in this volume. Sixty-eight scientists from sixteen countries attended. Prof. J. Bereiter-Hahn of Goethe-Universitat, Frankfurt, Germany, Prof. A.K. Harris of the University of North Carolina, Chapel Hill, USA, Prof. R.M. Nerem of Georgia Institute of Technology, Atlanta, USA and Prof. R. Skalak of the University of California, San Diego, USA were the members of the International Organizing Committee. As the Scientific Director of the Institute, I wish to express my sincere appreciation for their assistance without which the Institute could not have taken place. This Institute is the third one of the meetings which are now called "the NATO Istanbul Meetings on Cytomechanics". The first one was the NATO Advanced Research Workshop on Biomechanics of Cell Division which was held October 12-17, 1986 in Istanbul. The Proceedings were published as NATO ASI Series A Life Sciences Vol. 132 by Plenum Press in 1987. The second one was the NATO Advanced Study Institute on Biomechanics of Active Movement and Deformation of Cells which was held September 3-13, 1989 in Istanbul. The Proceedings were published as NATO ASI Series H : Cell Biology Vol. 42 by Springer-Verlag in 1990.

Klappentext

The book is the result of interdisciplinary collaboration between scientists from the diverse fields of cell biology, biomechanics, biophysics, biochemistry, engineering, mathematics, and computational sciences.BRIt provides detailed and appropriate mechanical explanations for the causes and consequences of active motion of cells, such as division, locomotion, shape change, and force generation. Also discussed is the applicability of the results in physiology, diagnosis and therapy.

Inhalt
Modelling of Biological Polymers: Discrete and Continuum Mechanics Formulations.- Cytokinesis: The Mechanism of Formation of the Contractile Ring in Animal Cell Division.- Effect of Cortex Stiffness Variation on Cleavage in Animal Cells.- Multicellular Mechanics in the Creation of Anatomical Structures.- The Interplay of Active Forces and Passive Mechanical Stresses in Animal Morphogenesis.- The Role of Elasticity in the Motile Behaviour of Cells.- On Free Boundary Problems and Amoeboid Motion.- A Model of the Leukocyte Migration Through Solid Tissue.- Adhesion and Traction Forces in Migration: Insights from Mathematical Models and Experiments.- The Active Response of an Endothelial Cell to the Onset of Flow.- Mechanical Aspects of Ciliary Propulsion.- Local Bending Fluctuations of the Cell Membrane.- Simulation of Morphogenetic Shape Changes Using the Finite Element Method.- Locomoting Blebbing Cells: A New Model to Test Whether Formation of Protrusions is Primarily due to Hydrostatic Pressure or to Actin Elongation.- Dynamic Morphology of Leukocytes: Statistical Analysis and a Stochastic Model for Receptor-Mediated Cell Motion and Orientation.- Observation, Modeling and Simulation of Keratinocyte Movement.- Strain Transduction in Non-Excitable Cells.- Self-Organization in Biological Systems as a Result of Interaction Between Active and Passive Mechanical Stresses: Mathematical Model.- Biomechanical Events in the Production of Ciliary Movement.- Microtubule Converging Centers: Implications for Microtubule Dynamics in Higher Plants.- Elastic Properties of Layered Membranes and Their Role in Transformations of Cellular Shapes.- Cortical Flow in Free-Living Amoebae.- A Mechanical Model for Growth and Control of the Cell Wall of Rod-Shaped Bacteria.- Measurement of Passiveand Active Force in Single Isolated Smooth Muscle Cells.- Molecular Mechanisms of Neutrophil Adhesion Studied by Inducing a High Avidity State at ?2-Integrin.- Mechanical Tension Regulates the Phenotype of Cells Cultured in a Collagen Gel.- The Mechanism of Actomyosin and Microtubule-Kinesin Systems.- Immunolocalization of Acetylated Microtubules in Germ Cells of Insects.- Mechanisms of ?1-Adrenergic Induced Positive Inotropism in Cardiac Cells.- Kinetochore Directional Instability in Vertebrate Mitotic Cells.- Signal Transduction and Myofibrillogenesis in Isolated Neonatal Heart Myocytes in Vitro.- Quantitative EMG and Biomechanics.- The Anaphase Movement and Its Relationship with Cell Cleavage.- Mechanism of Induction of Microspore Embryogenesis in Brassica napus: Significance of the Preprophase Band of Microtubules in the First Sporophytic Division.