Die Vor- und Nachteile der Hormonersatztherapie (HRT) werden von einer Expertengruppe hinsichtlich der epidemiologischen Beweislage diskutiert. Obwohl alle positiven und negativen Aspekte der HRT behandelt werden, liegt der Schwerpunkt der Diskussionen bei der Frage des Brustkrebsrisikos. Unter anderem wird gezeigt, dass die aus epidemiologischen Studien abgeleiteten Ergebnisse sich nicht mit den Wachstumseigenschaften dieser Tumoren decken so dass weiterführende Bevölkerungsuntersuchungen unter Einbeziehungen pathobiologischen Sachverstands notwendig erscheinen.

This volume contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) in modern postmenopausal women on the basis of the current evidence provided by recent epidemiological studies. It addresses all aspects of benefits and risks associated with HRT, including issues concerning psychology, the cardiovascular system, bone structure, and carcinogenesis. It focuses, however, on cancer risk and on risk of breast cancer in particular. In doing so, it provides a detailed discussion of the pathobiological features of breast cancer, concluding that the evidence provided by epidemiological studies is in conflict with the biological growth features of breast cancer. It advocates further epidemiological studies which incorporate pathobiological assessments.

Diskussion der Vor- und Nachteile der Hormonerstatztherapie Schwerpunkt der Diskussion ist Bruskrebsrisiko Contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) Addresses all aspects and risks associated with HRT Provides detailed review of controversy Includes supplementary material: sn.pub/extras

Inhalt
The Presentations.- to the Presentations.- Women Between Biology and Civilization.- Issues with the Term Responsibility.- Epidemiology of Selected Diseases in Women.- Pathogenesis of Histological Types of Endometrial Cancer.- Pathology of the Colon and Ovary.- The Progenitor Cell Concept of Proliferative Breast Disease.- Indication for HRT: Climacteric Complaints and Osteoporosis.- HRT and Cardiovascular Disease in Women.- The Million Women Study.- Paradigm Shift in Causal Thinking in Epidemiology.- Perception and Communication of Risk.- Some Thoughts After the Kloster Andechs Workshop, August 2003.- The General Discussion.- Menopause and the HRT Risk Benefit Equation: Status and Outlook.- Conclusions of the Kloster Andechs Workshop.- Workshop Consensus: The State of the Evidence.