This book reports the text of the lectures given at Tabiano, Sal so maggiore, Italy, during the Summer School on Bioenergetios and Thermodynamios: ModeZ Systems, in May 1979. The aim of the School has been that of trying to employ the thermodynamic data on synthesised organic compounds with special reference to macrocylic ligands for the interpretation and predic tion of energetic processes involving small and large molecules. A detailed description of the origin, scope and plan of the School can be found in the introductory lecture by A. Braibanti. In appendix to this lecture there are listed some introductory books recommended to achieve a sufficient background in the differ ent scientific fields contributing to the School. The audience consisted of about a hundred scientists belong ing to different fields. Physical, organic, inorganic, pharmaceut ical, analytical and medicinal chemists, biochemists, biophysicists, pharmacologists interested in the problems of calorimetry, poten tiometry, spectroscopy, transport properties of synthetic and natu ral chelates and macromolecules spent two weeks to discuss topics ranging from thermodynamics to electrochemistry, from measurements on pure compounds to determinations on membranes. This picture of the audience is an indication of researchers which can be interested in this book.

Proceedings of the NATO Advanced Study Institute, Tabiano, Parma, Italy, May 21-June 1, 1979

Klappentext

This book reports the text of the lectures given at Tabiano, Sal so­ maggiore, Italy, during the Summer School on Bioenergetios and Thermodynamios: ModeZ Systems, in May 1979. The aim of the School has been that of trying to employ the thermodynamic data on synthesised organic compounds with special reference to macrocylic ligands for the interpretation and predic­ tion of energetic processes involving small and large molecules. A detailed description of the origin, scope and plan of the School can be found in the introductory lecture by A. Braibanti. In appendix to this lecture there are listed some introductory books recommended to achieve a sufficient background in the differ­ ent scientific fields contributing to the School. The audience consisted of about a hundred scientists belong­ ing to different fields. Physical, organic, inorganic, pharmaceut­ ical, analytical and medicinal chemists, biochemists, biophysicists, pharmacologists interested in the problems of calorimetry, poten­ tiometry, spectroscopy, transport properties of synthetic and natu­ ral chelates and macromolecules spent two weeks to discuss topics ranging from thermodynamics to electrochemistry, from measurements on pure compounds to determinations on membranes. This picture of the audience is an indication of researchers which can be interested in this book.

Inhalt
Bioenergetics and Thermodynamics. Aims and Methodology of the School.- Design of Peptide Molecules to Mimic the Metal Binding Sites of Proteins.- Calorimetry and Biology.- Bioinorganic Chemistry of Nickel.- Design and Synthesis of Ligands.- Holes, Handedness, Handles, and Hopes: Meeting the Requirements of Primary Binding, Chirality, Secondary Interactions and Functionality in Enzyme Analogues.- Testing of Ligands.- Calorimetric Techniques to Study Proton-Ligand and Metal-Ligand Interactions.- Structural and Energetic Aspects of Metal-Ligand Binding.- Transport of Metal Ions by Liquid Membranes Containing Macrocyclic Carriers.- Enthalpy, Free-Energy, and Entropy Data for Structure-Activity Relationships in Acids and Bases.- Potentiometric and Spectroscopic Determination of Equilibrium Constants.- Experimental Data in Chemical and Biological Systems at Equilibrium.- What Concentration Scale? What Standard State? What Species are Present?.- Treatment and Analysis of Equilibrium Data by Computers.- Mixed Complexes.- Kinetics and Thermodynamics of Enzyme Action and Regulation.- Computer Models of Biological Systems.- Membranes, Alkali Metals and Transfer.- Synthetic Solvent-Polymeric Membranes and Their Transport Characteristics.- Macrocycles and Cation Selectivity.- Selectivity of Membranes Towards Ions and Molecules.- Transport Phenomena across Solid and Liquid Membranes.- Carriers and Channels in Artificial and Biological Membranes.- Lipid Bilayer Electrochemistry and -Role of the Carriers.- The Lipid Bilayer: A Model System for Biological Membranes.- Differential Scanning Calorimetry. Processes Involving Proteins.- Recent Advances in Biochemical Calorimetry.- Interpretation of Calorimetric Data from Cooperative Systems.- Selective Complexation of Ammonium and Guanidinium Salts by Synthetic Receptor Molecules.- Dynamical Aspects of Small-Molecule Protein Interaction.- Molecular Receptors, Carriers and Catalysts: Design, Scope and Prospects.- Metal Ions in Biological Systems.- Metal Ion Protein Interactions in Solutions.- Final Comments.- Contributing authors.