Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.
This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.

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Preface; J. Gilchrist, et al. 1. Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative; T. Nagasawa, et al. 2. Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot wines; R.S. Faustino, et al. 3. Absence of ischemic preconditioning protection in diabetic sheep hearts: role of sarcolemmal KATP channel dysfunction; H.F. del Valle, et al. 4. Protein Kinase B in the Diabetic Heart; B. Huisamen. 5. Inhibition of interleukin-1b convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs; M. Gyngysi, et al. 6. Effects of MCC-135 on Ca2+ uptake by Sarcoplasmic Reticulum and myofilament sensitivity to Ca2+ in isolated ventricular muscles of rats with diabetic cardiomyopathy; N. Satoh, Y. Kitada. 7. Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytrypamine in rats; D.N. Umrani, et al. 8. Mitogen-activate protein kinases in the acute diabetic myocardium; M. Strniskova, et al. 9. Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries; T. Matsubara, et al. 10. Arteriosclerosis in rat aortic allografts: Dynamics of cell growth, apoptosis and expression of extracellular matrix proteins; P. Religa, et al. 11. Effect of chronic treatment with losartan on streptozotocin-induced renal dysfunction; B. Murali, et al. 12. The relationship between human cytomegalovirus infection and atherosclerosis development; R. Chen, et al. 13. Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion; E. Aasum, et al. 14. A comparison between NMR and GCMS 13C-isotopomer analysis in cardiac metabolism; J.C. Chatham, et al. 15. Chronic diabetes alters function and expression of ryanodine receptor calcium release channels in rat hearts; K.R. Bidasee, et al. 16. The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus; A. Pourmoghaddas, A. Hekmatnia. 17. Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins; V.Z. Lankin, et al. 18. Native and minimally oxidized low density lipoproteins depress smooth muscle matrix metalloproteinase levels; D. Wilson, et al. 19. Low matrix metalloproteinase levels precede vascular lesion formation in the JCR:LA-cp rat; D. Wilson, et al. 20. Impairment of glucose metabolism and energy transfer in the hypertriglyceridemic rat heart; K. Carvajal, et al. 21. Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes; T. Ravingerov, et al. 22. Remodeling of the sarcolemma in diabetic rat hearts: The role of membrane fluidity; B. Ziegelhffer-Mihalovičov, et al.