This book provides an up-to-date overview of key areas of ageing research with a special focus on anti-ageing intervention strategies, which are currently very much at the forefront of ageing studies.

The volume discusses how dietary restriction, supplements or exercise affect the ageing process. Other intervention strategies reviewed are: chaperone activators, telomerase activation, hormetics, senolytics, NAD boosting, geroprotectors, stem cell therapies , resveratrol and melatonin, to just name a few. This book follows on from Parts I-IV of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and highlights anti-ageing intervention strategies that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientists alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.

Addresses the biochemistry and cell biology of anti-ageing interventions Reviews numerous anti-ageing interventions, e.g., exercise, dietary restrictions Also discusses effects of stem cell therapies on ageing

Autorentext
J. Robin Harris is an Honorary Professor of the University of Mainz, who specialized in macromolecular electron microscopy. He has been the Series Editor of the Subcellular Biochemistry Book Series for many years and his broad scientific interests are reflected in the diversity of content of the Series.

Viktor I. Korolchuk is a Professor of Cell Biology at Newcastle University, UK. His scientific interests lie in the area of intracellular protein trafficking and degradation pathways and their relevance to human health and ageing. The current focus of research in his laboratory is the key pro-longevity pathway called autophagy (literally self-eating) which is essential for cellular quality control and homeostasis.

Inhalt

Chapter 1: Telomerase-mediated anti-ageing interventions.- Chapter 2: Proteasome activators and ageing: restoring proteostasis using small molecules.- Chapter 3: Chaperone activators.- Chapter 4: NAD+ Boosting Strategies.- Chapter 5: Unlocking the Potential of Senolytic Compounds: Advancements, Opportunities, and Challenges in Ageing-Related Research.- Chapter 6: Stem Cell Therapies and Ageing: Unlocking the Potential of Regenerative Medicine.- Chapter 7: Diet-Modifiable Redox Alterations in Ageing and Cancer.- Chapter 8: The role of calorie restriction in modifying the ageing process through the regulation of SIRT1 expression.- Chapter 9: Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms.- Chapter 10: Hormetic effects of phytochemicals with anti-ageing properties.- Chapter 11: Melatonin As A Chronobiotic And Cytoprotector In Non-Communicable Diseases: More Than An Antioxidant.- Chapter 12: Role of vitamin B in healthy ageing and disease.- Chapter 13: Mineral supplements in Ageing.- Chapter 14: Gut Microbiome as a Target for Anti-ageing Interventions.