This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Thoroughly examines many different clinical science aspects of aging. Reviews exhaustively many important topics at an advanced level. Contains valuable insights for advanced biomedical science and medical students, postgraduates, researchers, clinicians and academics in the field of Ageing.

Autorentext

Klappentext
In recent years, volumes of the long-established Springer Subcellular Biochemistry series have shown great diversity of content, thus interesting biochemical topics, enthusiastically edited in all cases, have been readily accommodated.This new volume of the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part II, offers a broad overview of many different Clinical Science aspects of Ageing. The 17 chapters included in the book, contributed by knowledgeable authors, review many important topics at an advanced level. Whilst it has proved impossible to include all relevant topics, there is much present that will be of value to the reader.The book contains chapters on: Poor Early Growth and Age-associated Disease; The Immune System and its Dysregulation with Ageing; Pulmonary Diseases and Ageing; Neurodegenerative Diseases and Ageing; Ageing and Cognition; Ageing and Osteoarthritis; Down Syndrome, Ageing and Epigenetics; The Vestibular System and Ageing; Signal Transduction, Ageing and Disease; Skin Changes During Ageing; Connective Tissue and Age-related Diseases ; Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on the Ageing Process; Health Benefits of Anti-ageing Drugs; Visual Defects and Ageing; Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside; Osteoporosis and the Ageing Skeleton; Neurovascular Ageing and Age-related Diseases The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers, clinicians and academics in the field of Ageing. An earlier companion volume of the Subcellular Biochemistry series - Biochemistry and Cell Biology of Ageing: Part I (Volume 90) - covering the Biomedical Science aspects of ageing, has also been recently published.

Inhalt
Exercise, skeletal muscle and ageing.-Hypoxia and ageing.-Age-related disease and signal transduction.-Neurodegenerative diseases and ageing.-Immune system and its decline in ageing.-Osteoarthritis and ageing.-Vision: cataracts, glaucoma, macular degeneration, cornea....and ageing.-Type II Diabetes, obesity and ageing.-Atherosclerosis, CV Disease, hypertension and ageing.-Cancers and ageing.-Genetic (and epigenetic) disorders and ageing.-Poor early growth and age-related diseases.-Pulmonary diseases: COPD, bronchiectasis, pneumonia, asthma and ageing.-Skin changes during ageing.-Connective tissue ageing ECM matrix metalloproteinases.-Age-related hearing loss.-Inflammation and age-related diseases.-Human nutrition and ageing.-Virus disease in the elderly and vaccination: shingles HSV, influenza A, respiratory syncytial virus, cytomegalovirus, HIV.-Substance abuse: alcohol, drugs, smoking and ageing.-Pharmaceutical intervention and ageing.-Premature ageing / Progeroid syndromes.-Down's Syndrome and Ageing