This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Provides 17 chapters of up-to-date information on the biochemistry and cellular biology of aging processes in human cells Explores a number of the current key areas of research in subcellular aging research Examines topics such as mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging Illustrates the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition) Presents contributions from leading experts in the field

Autorentext
Prof. J. Robin Harris is an Honorary Professor of the University of Mainz, he has broad biomedical science and electron microscopical experience and is actively involved in scientific publishing. Dr. Viktor I. Korolchuk is a Reader in Molecular Cell Biology at Newcastle University and is actively involved in cellular autophagy studies.

Klappentext

This volume of the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part I is devoted broadly to Biomedical aspects of Ageing. The 17 chapters included in the book, contributed by knowledgeable authors, review many important topics at an advanced level.

Ageing in relation to reactive oxygen species (ROS) and the importance of Antioxidant Vitamins and Antioxidant Enzymes are given prominent coverage. Consideration is also given to Vitamin D and the B Vitamins. Chapters on Nutrition, Nutrient Sensing, the Microbiome and Signal Transduction appear, along with Cholesterol Metabolism, Creatine and Creatine Kinase, Extracellular Matrix, Stem cells, Nuclear DNA Damage, Teleomere Length, Gene Expression and Epigenetics, Autophagy and protein Glycosylation.

The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further supplementary volumeof the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part II, covering the more Clinical Science aspects of ageing, will be published soon.

Prof. J. Robin Harris is an Honorary Professor of the University of Mainz, he has broad biomedical science and electron microscopical experience and is actively involved in scientific publishing.

Dr. Viktor I. Korolchuk is a Reader in Molecular Cell Biology at Newcastle University and is actively involved in cellular autophagy studies.

Inhalt

ROS, Mitochondrial Damage and ageing.- Protein homeostasis, protein aggregation and ageing.- Chronic inflammation and ageing.- Metabolic changes in ageing.- Gene expression, epigenetics and ageing.- Antioxidant Vitamins and ageing.- Vitamin B Complex, folic acid and ageing.- Vitamin D, Osteoporosis and ageing.- Cellular DNA damage and ageing.- Telomere Length, telomerase and ageing.- Signal transduction pathways in ageing.- Creatine, Creatine Kinase and ageing.- Cellular senescence.- Autophagy and ageing.- Extracellular matrix proteins and ageing.- Stem cells and ageing.- mTOR and Ageing.- Nutrition and ageing.- Microbiome and ageing.- Cholesterol and Ageing.