Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.

Comprehensive critical reviews and original research papers from the 10th International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules Provides an in-depth analysis of cell surface macromolecules in cellular function Aimed at graduate students and researchers, but also appropriate for upper level undergraduates Includes supplementary material: sn.pub/extras

Inhalt

Human-Specific Evolutionary Changes in the Biology of Siglecs.- Structural Changes of GPI Anchor After Its Attachment to Proteins : Functional Significance.- Novel Insights In Membrane Biology Utilizing Fluorescence Recovery After Photobleaching.- Defects in Erythrocyte Membrane Skeletal Architecture.- Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55.- Immuno-Modulatory Role of Porins: Host Immune Responses, Signalling Mechanisms and Vaccine Potential.- Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical -barrel Pore-Forming Toxin.- New vis-tas in Lactosylceramide Research.- Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression.- A Signal with a Difference: The Role of GPI Anchor Signal Sequence in Dictating Conformation and Function of the Als5 Adhesin in Candida albicans.- Novel Chondroitin Sulfate Oligosaccharide Motifs as Biomarkers: Insights Into Their Involvement in Brain Development.- Role of Hyaluronidases in the Catabolism of Chondroitin Sulfate.- Pattern Recognition in Legume Lectins to Extrapolate Amino Acid Variability to Sugar Specificity.- Conformational Dynamics of Oligosaccharides Characterized by Paramagnetism-Assisted NMR Spectroscopy in Conjunction with Molecular Dynamics Simulation.- Characterization of Cholesterol Crystalline Domains in Model and Biological Membranes Using X-Ray Diffraction.- Role of Lipid-Mediated Effects in 2-Adrenergic Receptor Dimerization.- Effect of Temperature on the Phase Behaviour of Fully Saturated DAPC Lipid Bilayer: A Comparative Molecular Dynamics Simulation Study.- Biophysical Characterization of the Interaction of O-acylcholines with the Major Bovine Seminal Plasma Protein, PDC-109.- Crystal Structure of Apo and Ligand Bound Vibrio cholerae Ribokinase (Vc-RK): Role of Monovalent Cation Induced Activation and Structural Flexibility in Sugar Phosphorylation.- Synthetic Glycolipids and (p)ppGpp Analogs:Development of Inhibitors for Mycobacterial Growth, Biofilm and Stringent Response.- Regulations of Glycolipid : Glycosyltransferase (GSL: GLTs) Genes Involved in SA-LeX and Related GSLs Biosysthesis in Carcinoma Cells by Biosimilar Apoptotic Agents : Potential Anticancer Drugs.- N-acetylglucosaminyl 1-phosphate Transferase: An Excellent Target for Developing New Generation Breast Cancer Therapeutic.- Involvement of Vascular Endothelial Growth Factor in Serotonin 1A Receptor-Mediated Neuroproliferation in Neonatal Mouse Hippcampus.- Structural Heterogeneity of Glycoform of Alpha-1 Acid Glycoprotein in Alcoholic Cirrhosis Patients.